Gemcitabine and Docetaxel in Treating Patients With Recurrent Stage III or Stage IV Non-Small Cell Lung Cancer

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed stage IIIB or IV non-small cell lung cancer, including any of the following types:
• * Squamous cell carcinoma
• * Adenocarcinoma, including bronchoalveolar cell adenocarcinoma
• * Large cell anaplastic carcinoma, including giant and clear cell carcinomas
• Histologic or cytologic documentation of recurrence is required
• Measurable or evaluable disease, defined as any mass reproducibly measurable in 2 perpendicular diameters by physical examination or imaging
• * The following lesions are not considered measurable or evaluable:
• * Bone disease only
• * Pleural or pericardial effusions
• * Previously irradiated lesions, unless subsequent progression is documented
• CNS metastases allowed provided the patient undergoes at least 2 weeks of radiotherapy prior to study entry
• PATIENT CHARACTERISTICS:
• Not pregnant or nursing
• Fertile patients must use effective contraception
• Negative pregnancy test
• CALGB performance status ≤ 1
• Life expectancy ≥ 3 months
• Granulocyte count \> 1,500/mm\^3
• Platelet count ≥ 100,000/mm\^3
• Creatinine ≤ 2 times normal
• Bilirubin normal
• SGOT and/or SGPT ≤ 2.5 times upper limit of normal (ULN) AND alkaline phosphatase ≤ 1.5 times ULN OR
• Alkaline phosphatase 4 times ULN and SGOT and/or SGPT normal
• Ejection fraction normal by ECHO or MUGA
• No history of congestive heart failure
• No psychiatric illness that would preclude study compliance
• No serious medical or psychiatric illness that would preclude giving informed consent or limit survival to \< 3 months
• No active uncontrolled bacterial, fungal, or viral infection
• No other malignancy within the past 5 years except curatively treated carcinoma in situ of the cervix or breast, basal cell or squamous carcinoma of the skin, or other surgically resected non-recurrent primary tumor not treated with adjuvant radiotherapy or chemotherapy
• No pre-existing peripheral neuropathy ≥ grade 2
• PRIOR CONCURRENT THERAPY:
• At least 2 weeks since prior major surgery and recovered from acute effects
• At least 2 weeks since prior palliative radiotherapy and recovered from acute toxic effects
• * Any persistent toxicity (e.g., alopecia or hyperpigmentation) not associated with clinical morbidity allowed
• No prior chemotherapy
• No concurrent cranial or thoracic radiation therapy
• No concurrent cytotoxic or hormonal therapy
• Concurrent palliative radiotherapy allowed for relief of localized pain and obstruction