Clozapine Versus Chlorpromazine for Treatment-Unresponsive Schizophrenia

Inclusion Criteria

• •19-60 years of age
• •Diagnosis of schizophrenia
• •BPRS score \> 50
• •Clinical Global Impressions rating \> 4
• •One of the following: BPRS items rated greater than or equal to 4, conceptual disorganization, suspiciousness, hallucinations, unusual thought content.
• •At least 2 six-week trials of different neuroleptics given at a dosage equivalent to at least 600 mg per day of chlorpromazine OR at least 1 eight-week trial of a neuroleptic given at a dosage equivalent to at least 800 mg per day of chlorpromazine.
• •The patient (or the patient's authorized legal representative) must understand the nature of the study and sign the informed consent.