Raloxifene With or Without Exercise Compared With Exercise Alone in Women Who Have Been Previously Treated for Breast Cancer

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically confirmed breast cancer
• •No metastatic disease
• •At least 3 months but no more than 1 year since prior chemotherapy regimen including doxorubicin or methotrexate and catabolic steroids (to prevent nausea, vomiting, fluid retention, or hypersensitivity reactions)
• •No routine of regular strenuous exercise (more than 90 minutes per day 6 days/week OR 120 minutes per day 4 days/week)
• •Hormone receptor status:
• •* Estrogen and progesterone receptor negative OR
• •* Estrogen and progesterone receptor positive
• •PATIENT CHARACTERISTICS:
• •Age:
• •Any age
• •Sex:
• •Female
• •Menopausal status:
• •Postmenopausal (at diagnosis OR chemotherapy-induced)
• •No spontaneous menses for more than 6 months with increased follicle-stimulating hormone and decreased estradiol
• •Performance status:
• •Ambulatory
• •Life expectancy:
• •Not specified
• •Hematopoietic:
• •Not specified
• •Hepatic:
• •Not specified
• •Renal:
• •Not specified
• •Cardiovascular:
• •No cardiac problems that would preclude exercise
• •No unstable angina
• •Pulmonary:
• •No respiratory problems that would preclude exercise
• •No chronic obstructive pulmonary disease
• •No oxygen dependence
• •Other:
• •No endocrine disease (e.g., parathyroid hormone disorders) that would accelerate bone turnover and loss
• •No musculoskeletal problems or other disease that would preclude exercise (e.g., movement-limiting arthritis, muscular dystrophy, or chronic fatigue syndrome)
• •No known cognitive or psychiatric disorders that would preclude study
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •Not specified
• •Chemotherapy:
• •See Disease Characteristics
• •Prior adjuvant or neoadjuvant chemotherapy allowed
• •No concurrent chemotherapy
• •Endocrine therapy:
• •See Disease Characteristics
• •No concurrent tamoxifen
• •Radiotherapy:
• •Prior adjuvant radiotherapy after chemotherapy allowed
• •No concurrent radiotherapy
• •Surgery:
• •Not specified
• •Other:
• •No concurrent bisphosphonates