Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically diagnosed solid tumor (i.e., breast and ovarian epithelial carcinomas) or lymphoma
• •* Slides reviewed at the NCI Laboratory of Pathology
• •Failure on therapy of proven efficacy for the disease
• •* Prior therapy not required for the following metastatic diseases:
• •* Melanoma
• •* Non-small cell lung cancer
• •* Renal cell carcinoma
• •No brain metastases
• •* Primary brain tumors (such as glioblastoma multiforme) with stable neurologic deficits allowed
• •Measurable or evaluable disease required
• •* Demonstrated by physical exam or on radiograph within 2 weeks prior to initiation of treatment OR
• •* Elevated PSA associated with prostate cancer
• •* Other marker-only disease ineligible
• •PATIENT CHARACTERISTICS:
• •Age:
• •Over 18
• •Performance status:
• •ECOG 0-2
• •Life expectancy:
• •At least 3 months
• •Hematopoietic:
• •WBC at least 3,000/mm\^3
• •Platelet count at least 100,000/mm\^3
• •Hematocrit at least 27%
• •Hepatic:
• •Liver function tests no greater than 2 times upper limit of normal
• •Bilirubin normal
• •PT or PTT no greater than 1.25 times upper limit of normal
• •Clotting parameters normal
• •No concurrent anticoagulants other than 1 mg of warfarin per day for prophylaxis
• •Renal:
• •Creatinine no greater than 1.5 mg/dL OR
• •Creatinine clearance at least 45 mL/min
• •No kidney obstruction
• •Cardiovascular:
• •No cardiac conduction defect requiring antiarrhythmics
• •No evidence of myocardial infarction or other myocardial damage within past 6 months
• •Other:
• •HIV negative
• •No concurrent infection
• •No guaiac-positive stool test
• •No neuropathy greater than grade I (unless associated with fixed-deficit primary brain tumors)
• •Not pregnant or nursing
• •Fertile patients must use effective contraception during and for 2 months after study
• •PRIOR CONCURRENT THERAPY:
• •Recovery from prior therapy required
• •Biologic therapy:
• •At least 4 weeks since prior biologic therapy
• •Chemotherapy:
• •At least 4 weeks since prior chemotherapy (6 weeks since mitomycin, nitrosoureas, or carboplatin)
• •No progression on carboxyamidotriazole or paclitaxel
• •At least 6 months between treatment and relapse
• •Endocrine therapy:
• •At least 4 weeks since prior hormonal therapy
• •No concurrent corticosteroids except as physiologic replacement
• •Radiotherapy:
• •At least 4 weeks since prior radiotherapy
• •Surgery:
• •Not specified
• •Other:
• •At least 1 week since prior therapeutic antibiotics
• •Concurrent prophylactic antibiotics allowed except imidazole antifungals (e.g., ketoconazole, fluconazole)
• •No concurrent calcium channel blockers