Inhaled Doxorubicin in Treating Patients With Primary Lung Cancer or Lung Metastases

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed primary lung cancer or cancer metastatic to the lung that is not potentially curable by standard chemotherapy, radiotherapy, or surgery
• * Bronchoalveolar cell lung cancer allowed
• Lung metastases from soft tissue sarcoma allowed
• No leukemia or lymphoma
• PATIENT CHARACTERISTICS:
• Age:
• 18 and over
• Performance status:
• Karnofsky 70-100%
• Life expectancy:
• Not specified
• Hematopoietic:
• WBC at least 4,000/mm\^3
• Platelet count at least 160,000/mm\^3
• Hemoglobin at least 9 g/dL
• Hepatic:
• Bilirubin no greater than 1.0 mg/dL
• AST/ALT less than 1.5 times upper limit of normal
• Renal:
• Creatinine no greater than 1.2 mg/dL OR
• Creatinine clearance at least 50 mL/min
• Cardiovascular:
• LVEF normal by MUGA scan or echocardiography
• No unstable angina
• No congestive heart failure
• No symptomatic arrhythmias
• Pulmonary:
• DLCO at least 65% of normal
• FVC at least 50% predicted
• FEV1 at least 50% predicted
• Resting oxygen saturation at least 90%
• Exercise oxygen saturation at least 85%
• No complete atelectasis
• No asthma
• Other:
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 6 months after study
• No congenital problems (e.g., cleft palate) or other anomalies that would prevent tight fit of mouth seal
• No other concurrent illness that would preclude study therapy
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• Not specified
• Chemotherapy:
• See Disease Characteristics
• At least 3 weeks since prior chemotherapy and recovered
• No prior bleomycin or nitrosoureas
• No prior mitomycin greater than 25 mg/m\^2
• No prior anthracyclines greater than 450 mg/m\^2
• No other concurrent chemotherapy
• Endocrine therapy:
• Not specified
• Radiotherapy:
• See Disease Characteristics
• At least 3 weeks since prior radiotherapy and recovered
• No prior chest (pulmonary or mediastinal) or thoracic spine radiotherapy
• * Patients with only chest wall or primary breast radiation are eligible
• No concurrent thoracic irradiation
• Surgery:
• See Disease Characteristics
• No prior pneumonectomy
• Other:
• No daily or as necessary respiratory drugs via inhaler or nebulizer
• No other concurrent experimental drugs