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1–20 of 8,508
Completed
Safety and Efficacy of Pembrolizumab (MK-3475) Plus Binimetinib Alone or Pembrolizumab Plus Chemotherapy With or Without Binimetinib in Metastatic Colorectal Cancer (mCRC) Participants (MK-3475-651/KEYNOTE-651)
The purpose of this study is to determine safety and tolerability and to establish a preliminary recommended Phase 2 dose (RP2D) for the following combinations: pembrolizumab plus…
NCT03374254
·
Duarte, California and 13 others
Completed
hTERT Immunotherapy Alone or in Combination With IL-12 DNA Followed by Electroporation in Adults With Solid Tumors at High Risk of Relapse
This is a Phase I, open label study to evaluate the safety, tolerability, and immunogenicity of INO-1400 or INO-1401 alone or in combination with INO-9012, delivered by…
NCT02960594
·
Detroit, Michigan and 5 others
Not yet recruiting
Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancers Without Liver Metastases
The goal of this clinical trial is to evaluate the superiority of ivonescimab combined with FOLFIRI over FOLFIRI + bevacizumab as second-line treatment of non resectable pMMR/MSS…
NCT07359456
·
Auxerre and 21 others
Unknown
A Prospective Multi-centered Randomized Controlled Trial on Fruquintinib in Combination With HAIC in the Treatment of Liver Metastatic Colorectal Cancer After Failure of Second-line Systematic Therapy
The current study is to investigate the safety and efficacy of fruquintinib combined with HAIC in patients with advanced colorectal liver metastases who have failed second-line…
NCT05511051
·
Beijing and 2 others
Active not recruiting
Impact of Environmental Factors and Metabolomics on Colorectal Cancer.
Colorectal cancer is one of the malignant tumours with high morbidity and mortality worldwide, posing a serious threat to human health.
NCT06643429
·
Chongqing, Chongqing Municipality
Completed
Exercise as Medicine for People With Cancer Sweden
Regular exercise has been shown to have beneficial health effects in cancer survivors, including improving quality of life and other important health outcomes.
NCT05064670
·
Stockholm
Terminated
Organ-sparing With TraceIT® for Rectal Cancer Radiotherapy
For advanced rectal tumors, the standard of care is neoadjuvant radiotherapy (RT) +/- chemotherapy followed by surgery 8-10 weeks later.
NCT03258541
·
Geneva
Completed
Pharmacodynamic Evaluation of Stool Output Following Oral Administration of Various Low Volume PEG3350-based Gut Cleansing Solutions Using the Split Dose Intake in Healthy Subjects
This study is to investigate the effect of various modified low volume polyethylene glycol (PEG) 3350 and ascorbic acid/ascorbate (PEG+ASC)-based gut cleansing solutions on stool…
NCT01834742
·
Timișoara and 1 other
Recruiting
Sample Collection for Ongoing Research and Product Evaluation Study
The SCORE study is a prospective, multi-site clinical trial designed to collect blood and tissue samples, along with relevant clinical data, from participants diagnosed with…
NCT07318051
·
Austin, Texas
Unknown
Total Neoadjuvant Therapy in Rectal Cancer Treatment
This is a randomized, controlled, parallel study to determine the efficiency and safety of total neoadjuvant therapy in rectal cancer treatment.
NCT04747951
·
Moscow
Completed
Anal Cancer Screening Study
Background: * HIV-positive men who have sex with men (MSM) have rates of anal cancer that approach those of cervical cancer in women.
NCT00914537
·
San Francisco, California
Completed
Perfusion Assessment in Laparoscopic Left Anterior Resection
The purpose of this study is to demonstrate that NIR fluorescence angiography using the PINPOINT Endoscopic Fluorescence Imaging System ("PINPOINT System" or "PINPOINT") can…
NCT01560377
·
Los Angeles, California and 10 others
Unknown
Combination Chemotherapy With or Without Cetuximab Before and After Surgery in Treating Patients With Resectable Liver Metastases Caused By Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, fluorouracil, leucovorin, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing…
NCT00482222
·
Basildon, England and 21 others
Completed
Educational Intervention - Improving Knowledge and Screening Rates for Colorectal Cancer
This clinical trial studies how well educational intervention works in improving knowledge and screening rates of colorectal cancer.
NCT03287453
·
Columbus, Ohio
Completed
Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma
This is a Phase I dose escalation study of PXD101 administered orally. Oral belinostat will be given once or twice daily at various dosing schedules to patients with solid tumors.
NCT00413075
·
New Haven, Connecticut and 5 others
Completed
Bacterial Translocation Markers as Predictors of Infectious and Inflammatory Complications in Acute Bowel Obstruction
Despite modern approaches to the diagnosis and treatment of acute bowel obstruction (ABO), postoperative mortality ranges from 5 to 32%, and complications occur up 23% of cases.
NCT05229822
·
Karaganda
Completed
Implementing Fit Kit Colorectal Cancer (CRC) Screening in High Risk Populations
The purpose of this study is to understand best strategies for engaging high risk populations in a primary care setting to improved adherence to colorectal cancer screening…
NCT04848051
·
New Haven, Connecticut
Recruiting
A Multicenter Cancer Biospecimen Collection Study
This study will collect de-identified tumor samples, with correlated clinical/demographic data and tissue histology, from patients selected or scheduled for pre-treatment tumor…
NCT04510129
·
San Francisco, California
Completed
Preoperative Immunonutrition in Normonourished Patients Undergoing Fast-track Laparoscopic Colorectal Surgery
Immunonutrition (IN) appears to reduce infective complications and in-hospital length of stay (LOS) after gastrointestinal surgery.
NCT04692545
Terminated
Irinotecan Plus E7820 Versus FOLFIRI in Second-Line Therapy in Patients With Locally Advanced or Metastatic Colon or Rectal Cancer
The purpose of the Phase Ib portion is to find out the highest dose of study drug that can safely be given when tested in a small group of subjects.
NCT01347645
·
Birmingham, Alabama and 37 others
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