Study and Monitoring of Early Undifferentiated Arthritis

NCT03666091

The French Society of Rheumatology initiated a large national multicenter, longitudinal and prospective cohort, ESPOIR, in order to set up databases to allow various investigations on diagnosis, prognostic markers, epidemiology, pathogenesis and medico-economic factors in the field of early arthritis and rheumatoid arthritis. The primary objective is to set-up a multicentre cohort of early arthritis (less than 6 months) in France that could serve as a database to studies of various natures. Specific objectives are in the following domains: * diagnosis: to help determine among clinical, biological, radiographic and immunogenetics those parameters allowing for the earliest diagnosis classification as possible, in order to target early therapy; * prognosis: to identify early those patients at risk of severe disease by investigating among clinical, biological, genetic and sociologic factors; * medico-economic: to identify the costs and their determinants at various disease stage; * pathologic: to collect a databank of sera, DNA, RNA to allow for studies of transcriptomes and other genomics. Secondary objectives are twofold: * to monitor adverse events, particularly rare drug adverse events, in collaboration with other international studies * to allow access to the data collected in this cohort study in order to facilitate new projects submitted to and approved by the scientific committee.