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Showing 1-20 of 28 trials
NCT07548541
This randomized, double-blind, four-period crossover trial investigates the acute effects of creatine monohydrate, L-arginine, and their combined administration on anaerobic performance, jump performance, and cognitive reaction time in recreationally active adult males. Eighteen healthy male participants complete four experimental conditions in randomized order: placebo, creatine, L-arginine, and creatine plus L-arginine, with at least 72 hours between sessions. Sixty minutes after supplementation, participants perform the Stroop Color-Word Test, countermovement jump test, and Running-Based Anaerobic Sprint Test. Primary outcomes include peak power, average power, countermovement jump height, and incongruent Stroop reaction time. The study aims to determine whether acute co-supplementation produces greater ergogenic and cognitive benefits than either supplement alone or placebo.
NCT07438236
This study investigates the effect of dietary supplementation on cognitive Performance and mood in university students over a 60-day period using a double-blind randomized controlled design. This study includes 75 participants, aged 18 or older. Participants will be randomly assigned to group I (n=25; will receive the supplement one), group II (n=25; will receive the supplement two), and group III (n=25; control/placebo). Assessments will be conducted before starting supplementation, 30 days after, and at the end of the intervention to determine the effect of the supplementation on cognitive performance and mood. The main outcomes include cognitive status and mood measured by Depression Anxiety Stress Scales - (DASS), Brief Symptom Inventory (BSI) and Self-efficacy scale in higher education. Adherence to supplementation and potential side effects will also be assessed. Based on the data obtained at these three assessment points, it will be possible to qualitatively address the actual effect of supplements on students' cognitive performance. In addition, the participants nutritional status will also be assessed using the Simplified Appetite Nutrition Questionnaire (SANQ) and their perception of it using the Visual Appetite Scale (VAS). Both measurements will take place before the start of supplementation and at the end of the intervention.
NCT07379879
This study examines whether the intensity of a single running session changes a blood marker related to brain health (brain-derived neurotrophic factor, BDNF), blood lactate, and performance on a short thinking task that measures attention and self-control (the Stroop test) in healthy young adult men. Twelve healthy males (18-25 years) will complete four separate sessions in a randomized, counterbalanced order, with at least 7 days between sessions. Each session includes an 8-minute warm-up followed by 24 minutes of one of the following conditions: low-intensity continuous running, moderate-intensity continuous running, high-intensity interval running (repeated 15-second fast runs with 15-second passive rest, organized into sets), or a seated rest control session. Running pace will be individualized based on a prior fitness test. A small venous blood sample (about 8 mL) will be collected immediately before and within 1 minute after each session. After each session, participants will complete the Stroop test. The main outcomes are the before-to-after changes in serum BDNF, blood lactate, and Stroop test performance across the four conditions.
NCT04856410
This study investigates the effects of extended-duration spaceflight (12-month International Space Station missions) on general cognitive performance (measured with the Cognition test battery), spatial cognition, structural and functional brain changes in general, and hippocampal plasticity more specifically relative to the shorter 6-month and 2-month missions.
NCT06489873
The goal of this clinical trial is to learn the impact of lutein, zeaxanthin, and fish oil (LZF) supplementation in healthy adults. The main question it aims to answer is: Will supplementation with LZF improve macular pigment optical density (MPOD), cognitive performance and bone mass compared to controls after six months? Subjects with an MPOD \<.43 will significantly improve MPOD after 6-months of LZF supplementation. Consuming a LZFO supplement for 6-months will improve visual cognitive performance. Consuming a LZFO supplement for 6-months will improve bone density. Participants will be asked to take either a LZF supplement or placebo daily for 6 months.
NCT03771716
REACT is a randomized intervention to examine the benefits of African Dance as a method to increase physical activity behaviors in older adults. In this 6- month intervention, older African Americans will be randomly assigned to either an African Dance or an Africana Culture class. Both before and at the completion of the intervention, the investigators will collect a comprehensive neuropsychological battery and MRI scans of brain health and function to better study how physical activity influences neurocognitive health in African Americans.
NCT07103837
Aging is associated with cognitive and physical decline, leading to an increased risk of falls in older adults. Recent evidence highlights the critical role of cognitive functions-such as attention, memory, and executive functioning-in postural control and fall risk. This study aims to develop and validate a novel Reactive Skill Test (RST) that simultaneously assesses cognitive (reaction time, visual attention, short-term memory) and motor responses in older adults. The test involves matching colored stimuli to targets using a color-coded pod and cone setup controlled via the ReactionX system. The validity of RST will be examined through correlations with established cognitive and fall risk measures, while test-retest reliability will be assessed across separate sessions. This tool may provide early detection of cognitive-motor impairments contributing to fall risk in aging populations.
NCT04833010
To describe the primary and secondary outcomes of athletes during a Cardiopulmonary Exercise Test (CPET) on a cycle ergometer with and without a face mask.
NCT06693505
This study aimed to examine the impact of caffeinated chewing gum on the cognitive performance of night-shift emergency physicians in a partially sleep-deprived state. A randomized, double-blind crossover controlled experimental design was employed in which fourteen (Age: 29.9 ± 1.44; height: 176.5±5.3; weight: 78.1±13.4) emergency physicians consumed either caffeinated chewing gum (CAF) containing 200 mg caffeine or a caffeine-free placebo gum (PLA) for 10 minutes at 03:30 am during their first 8-hour night shift after at least one day off, and completed cognitive performance tests before shift, mid-shift (10 minutes after gum chewing), and after shift, including included Corsi block test, Task-switching paradigm, Stroop Test, Visual search, and Wisconsin Card Sorting Task. Sleep quality was assessed subjectively by a single question score, and objectively by ActiGraph for one night on the off day and the last sleep before the first night shift, to evaluate the effect of sleep quality on cognitive performance.
NCT05653141
Present study aims to track the post-stroke cognitive trajectories and to investigate its inter-individual variability.
NCT06684808
The purpose of the study was to evaluate the effects of 12 weeks of Active Breaks on motor, academic and cognitive performance in elementary school children.
NCT05724654
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is also associated with cognitive decline. Peanut consumption has already been shown to beneficially affect cognitive performance. However, underlying mechanisms have not yet been established, while well-controlled trials on longer-term effects of peanuts on cognitive performance are highly needed. The hypothesis is that longer-term peanut consumption has beneficial effects on (regional) cerebral blood flow responses (primary outcome), which may relate to an improved cognitive performance (secondary outcome) in older men and women. Important objectives are to investigate in older adults the effect of 16-week peanut consumption on (i) brain vascular function in cognitive-control brain areas, and (ii) brain insulin-sensitivity. We will also focus on changes in cognitive performance as assessed with a neuropsychological test battery (secondary objective). Cerebral blood flow responses before (brain vascular function) and after the administration of intranasal insulin (brain insulin-sensitivity) will be quantified by the non-invasive gold standard magnetic resonance imaging (MRI)-perfusion method Arterial Spin Labeling (ASL).
NCT03567343
This study seeks to observe the effects of a proprietary spearmint extract and green tea blend on sleep quality and duration. The study observes the effect of the supplement regarding sleep quality, and mental health.
NCT05260801
The lockdowns and restrictions associated with the COVID-19 have created a seismic shift in where work is done. Prior to the pandemic, approximately 20% of individuals were working from home while during the pandemic, more than 70% of individuals worked from home. While it is unlikely that such a large percent of the population will remain working from home, the vast support from workers for such work arrangements and the potential increase in productivity means that there will likely be a revision of the work place with more individuals working from a home office environment than have done so in the past. One unintended aspect of working from home is a reduction in light exposure, especially in the contrast between the daytime and evening. Offices converted from bedrooms, basements, and kitchens are often illuminated in the recommended 50-100 lux range, as opposed to the approximately 500 lux of most offices. While this light intensity is sufficient to work or read by, it may be insufficient to maintain adequate mental and physical health. In addition to light allowing us to consciously perceive the world around us, light can also induce a variety of changes in physiology that can impact our health, notably inducing shifts in the timing of circadian rhythms, suppressing the onset of melatonin production, and increasing alertness with subsequent changes to sleep latency and architecture. These changes in sleep and circadian rhythms have been associated with a variety of pathologies including increased risk of metabolic, psychiatric, cognitive, and cardiovascular disorders, in addition to overall longevity. Development of an adequate prophylactic countermeasure for the circadian desynchrony to which home office workers are exposed is a critical step in maintaining the health of these individuals. There are two main studies. The first study (Years 1-2) will be an in-laboratory determination of the threshold of light needed to minimize the negative impact of nocturnal light exposure. The second study (Years 3-4) will be a field study applying this threshold to determine if whether in situ use of this light intensity during the day improves health and safety among home office workers. Current CT.gov represents the second part of this study i.e. "Study 2: The impact of daytime light intensity in home workplaces on health and well-being of remote workers. In study 2, investigators will examine a series of participants (N=36), each of whom will participate in a five-week experiment. Each participant will have a screening visit at their home. The study will be conducted over five successive one-week periods with two cohorts of participants experiencing the same series of lighting interventions. All data collection will be performed during the working days (Monday - Friday) when participants are exposed to the lighting in their home offices.
NCT05073406
The aim of the current study is to evaluate under blinded conditions, both in a simulated environment and during helicopter flight, the effect of a rapid (within 20 minutes) exposure to altitude (4000 m asl) on physiological parameters and selected cognitive domains, in providers operating in helicopter emergency medical service (HEMS) exposed to hypobaric hypoxia or to hypobaric normoxia (H0: cognitive effects under hypobaric hypoxia = cognitive effects under hypobaric normoxia). Simulated environment will allow to control different factors. The parallelism between a study branch conducted in a simulated environment and another one conducted under a real-life condition will allow to evaluate the additive effects on additional stressor factors (processive and systemic ones). * Simulation branch: each participant will take part in three research sessions: a familiarization session and two experimental sessions in simulation facility called terraXcube (test 1 and 2). On test 1 and test 2 each group will be exposed twice to the simulated altitude of 4000 m asl (under hypobaric hypoxia or hypobaric normoxia conditions) according to the randomization protocol. Participants will perform the neurocognitive tests three times on each of the two tests: before the ascent (TC0), after 5 min from the end of the ascent (TC1) and after around 30 min (TC2), to investigate European Union Aviation Safe Agency (EASA) proposed recommendations. After completing each neurocognitive test session, participants will be asked to rate their performance using a visual analogue scales (VAS). All participants will wear the vital parameters monitoring system during the entire duration of the tests inside the chamber, as well as the cerebral oxygen saturation (ScO2) sensor. Samples will be collected by saliva, urine and/or capillary blood. The same schedule is repeated in each test session. * In-field branch: each participant will take part in three research sessions: a familiarization session and two experimental sessions during helicopter flights (test 1 and 2). On test 1 and test 2 each group will be exposed twice to the altitude of 4000 m (under hypobaric hypoxia or hypobaric normoxia conditions) according to the randomization protocol. Participants will perform the neurocognitive test two times on each test: before the ascent (TC0), after around 5 min from the end of the ascent (TC1). After completing each neurocognitive tests, participants will be asked to rate their performance using a visual analogue scales (VAS). All participants will wear the vital parameters monitoring system during the entire duration of the tests. Samples will be collected. The same schedule is planned in each test session.
NCT05498129
This trial investigated the impact of providing a regular meal with and without additional multiple micronutrients for children in Northwest Pakistan on their performance at school, in comparison to a local government school that served as a control i.e. no school meal.
NCT05032729
The primary objective is to assess the impact of two nutritional interventions vs. placebo on objective and subjective sleep measures in athletes. Participants receive one beverage on each of three consecutive nights in a randomized manner. It is hypothesized the two nutritional interventions will result in significant improvements in sleep onset latency, and will not result in a negative impact on next-day cycling performance. The secondary objective is to assess the impact of the nutritional interventions vs. placebo on next-morning performance (physical, cognitive function, and balance).
NCT05226039
The current clinical study will have two groups of participants (young adults ages 20 - 30, and older adults ages 60 - 70) take part in three visits to the lab. On the first visit participants will fill out questionnaires assessing demographics and physical activity level. On the 2nd and 3rd visits participants will be engage in both a moderate intensity bout of aerobic exercise for 20 minutes, and 20 minutes of resting on a stationary bike watching an educational video. These two visits will be counterbalanced across age groups. Following both the exercise bout and the resting control condition participants will complete cognitive tasks assessing episodic memory and executive functioning. The first hypothesis is that older adults who are more physically active (assessed via questionnaire) will have significantly greater cognitive abilities compared to those who are less active or sedentary. The second hypothesis is that following a single bout of moderate intensity aerobic exercise, older adults will have a greater magnitude of change in their short-term memory, and long-term memory performance compared to younger adults.
NCT05204823
The objective of the study is to evaluate the glycemic index and glycemic load of 4 chocolate milk drinks.
NCT04974606
The primary purpose is to test the short-term effects of the acute consumption of two novel beverages made from coffeeberries, the fruit of the coffee plant (Coffea arabica) benchmarked against caffeine on several aspects of cognitive performance. Preliminary studies suggest that flavanols and chlorogenic acids can enhance cognitive performance. It is unknown if drinks formulated with flavanols and chlorogenic acids (without high sugar or caffeine) improve cognition or mood to a similar extent as caffeine. Coffeeberry beverage comparisons will be made to a flavored positive control beverage containing caffeine and a flavored placebo beverage.