Clinical Trials in Texas

Showing 1621-1640 of 12,973 trials

COMPASSION S3 Post-Approval Study

NCT04860765

This study will monitor device performance and outcomes of the SAPIEN 3 Transcatheter Heart Valve (THV) System in subjects with a dysfunctional right ventricular outflow tract (RVOT) conduit or previously implanted surgical valve in the pulmonic position with a clinical indication for intervention.

Complex Congenital Heart DefectDysfunctional RVOT ConduitPulmonary Valve Insufficiency+2 more

Edwards Lifesciences150 participantsStarted Apr 2021

Birmingham, Alabama, United States • Los Angeles, California, United States • Aurora, Colorado, United States +16 more locations

RECRUITINGPhase 3119 miles

A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARB

NCT05183646

DMX-200 (repagermanium) is a C-C chemokine receptor type 2 (CCR2) inhibitor that, when administered concurrently with an ARB, is designed to inhibit recruitment of monocytes implicated in the inflammatory chemokine environment of chronic disease. The purpose of this pivotal randomized double-blind study is to investigate the efficacy and safety of DMX-200 120 mg twice daily (BID) compared with placebo over a treatment period of 104 weeks in adult patients with FSGS who are being treated with an ARB. Given the rarity of the disease and the similarities between adults and pediatric patients with FSGS, Dimerix will also investigate the efficacy and safety of DMX 200 in adolescents aged 12 to 17 years. The double-blind period will be followed by an open-label extension (OLE) which aims to assess the long-term efficacy and safety of DMX 200 for up to 2 additional years.

FSGS

Dimerix Bioscience Pty Ltd286 participantsStarted May 2022

Birmingham, Alabama, United States • Phoenix, Arizona, United States • Phoenix, Arizona, United States +217 more locations

COMPASSION S3 Post-Approval Study

A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARB

Find Trials by Condition in Texas

A Study to Test a Medicine (Fitusiran) Injected Under the Skin for Preventing Bleeding Episodes in Male Adolescent or Adult Participants With Severe Hemophilia

A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

Oral ISL QM as PrEP in Cisgender Women at High Risk for HIV-1 Infection (MK-8591-022)

A Study About How TAK-881 is Processed by the Body and Side Effects in People With Primary Immunodeficiency Diseases

A Study of Avoralstat In Participants With Diabetic Macular Edema

A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours

A Phase 2b Study of Zagociguat in Patients With MELAS

A Study to Find a Suitable Dose of BI 765883 and to Test Whether it Helps People With Advanced Pancreatic Cancer When Taken Alone or Together With Chemotherapy

A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer

PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

HYDRAFIL-D: HYDRogel Augmentation For Intervertebral Lumbar Discs

A Study to Test DSP107 in Combination With Atezolizumab in Comparison With Fruquintinib as a New Treatment for Colorectal Cancer.

PILOT for The Precision Exercise Regimen for Cancer Care (PERCC) Study

VIGOR: Virtual Genome Center for Infant Health

Physical Activity Smartphone App for African American Men (FitBros) Ph II

Roll-over Study to Allow Access to Certinib (LDK378) for Patients Who Are on Ceritinib Treatment in a Novartis-sponsored Study

Genetic Analysis of Blood and Tissue Samples From Patients With Advanced Cancer, Moonshot Study

Gene Expression in Patients With Metastatic Prostate Cancer Receiving CYP-17 Inhibition Therapy