Clinical Trials in Tennessee

Showing 18961-18980 of 20,239 trials

Study of Oral AEE788 in Adults With Advanced Cancer

NCT00118456

AEE788 is an orally active, reversible, small-molecule, multi-targeted kinase inhibitor with potent inhibitory activity against ErbB and VEGF receptor family of tyrosine kinases. It has an IC50 of less than 100 nM against p-EGFR, p-ErbB2, and p-KDR (VEGFR2). This study will assess the safety, pharmacokinetic (PK)/pharmacodynamic (PD) profiles and clinical activity of AEE788 in advanced cancers.

Cancer

Novartis Pharmaceuticals189 participantsStarted Jul 2003

New Haven, Connecticut, United States • Las Vegas, Nevada, United States • Nashville, Tennessee, United States +2 more locations

COMPLETEDPhase 229 miles

Study of LX3305 in Subjects With Active Rheumatoid Arthritis on Stable Methotrexate

NCT00903383

The purpose of the study is to evaluate the safety, tolerability, and effectiveness of LX3305 versus a placebo control in subjects with active rheumatoid arthritis on stable methotrexate therapy.

Rheumatoid Arthritis

Lexicon Pharmaceuticals208 participantsStarted Jul 2009

Gainesville, Florida, United States • Orange Park, Florida, United States • Orlando, Florida, United States +35 more locations

Study of Oral AEE788 in Adults With Advanced Cancer

Study of LX3305 in Subjects With Active Rheumatoid Arthritis on Stable Methotrexate

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The Effect of Primary Care Interventions on Children's Media Viewing Habits and Exposure to Violence

Pharmacogenomic Biomarker Study for Recombinant Human Activated Protein C Treatment in Severe Sepsis

A Safety and Tolerability Study of Azilsartan Medoxomil in Participants With Essential Hypertension

A Study of Mycophenolate Mofetil (CellCept) in Management of Patients With Lupus Nephritis.

Effect of Cabazitaxel on the QTc Interval in Cancer Patients

Hormone Therapy in Treating Postmenopausal Women With Receptor-Positive Breast Cancer

Evaluation of a Human Immunodeficiency Virus (HIV) Blood Screening Assay

Treatment of ADHD With Atomoxetine in Children & Adolescents With ADHD & Comorbid Dyslexia

Efficacy and Safety Study of JNJ-32729463 Compared With Moxifloxacin for the Treatment of Subjects Requiring Hospitalization for Community-Acquired Bacterial Pneumonia

Study Evaluating the Safety and Effects of MN-221 in Subjects With Moderate to Severe Asthma

Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity

POCARED Diagnostics, LTD, Field Study Protocol

Paclitaxel in Treating Patients With Unresectable Locally Advanced or Metastatic Pancreatic Cancer

Preliminary Longitudinal Validation of Biomarkers Predictive of Barrett's Esophagus

A Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Osteoarthritis of the Knee

Injection Assistance Device Versus Manual Injections for Delivery of Dermal Fillers

Pre-Mix Insulin Lispro Treatment for Type 2 Diabetes Patients Who Consume a Light Breakfast

Safety Study of PRLX 93936 in Patients With Advanced Solid Tumors