Clinical Trials in Tennessee

Showing 15421-15440 of 20,239 trials

A Study of PI3-Kinase Inhibitor GDC-0941 in Combination With Paclitaxel, With and Without Bevacizumab or Trastuzumab, and With Letrozole, in Participants With Locally Recurrent or Metastatic Breast Cancer

NCT00960960

This is an open-label, multicenter, Phase Ib dose-escalation study to assess the safety, tolerability, and pharmacokinetics of oral (PO) pictilisib administered with letrozole or intravenous (IV) paclitaxel with and without IV bevacizumab or IV trastuzumab in participants with locally recurrent or metastatic breast cancer. The study consists of three parts. Part 1 (pictilisib will be administered in 21+7 schedule along with paclitaxel and/or bevacizumab), Part 2 (pictilisib will be administered in 5+2 schedule along with paclitaxel and/or bevacizumab or trastuzumab) and Part 3 (pictilisib will be administered in combination with letrozole). Part 1 and Part 2 consists of two stages; a dose escalation stage and a cohort-expansion stage.

Breast Cancer

Genentech, Inc.71 participantsStarted Aug 2009

Peoria, Illinois, United States • Boston, Massachusetts, United States • Nashville, Tennessee, United States +2 more locations

COMPLETEDPhase 1/229 miles

Trial of Antimycobacterial Therapy in Sarcoidosis

NCT01074554

Growing research from independent laboratories provide an association between mycobacteria and sarcoidosis. More recent immunologic and molecular studies demonstrate immune responses to mycobacteria virulence factors. The purpose of this study is to assess if administration of anti-mycobacterial drug therapy will aid in resolution of cutaneous sarcoidosis lesions.

Sarcoidosis

Vanderbilt University30 participantsStarted Feb 2010

Nashville, Tennessee, United States

A Study of PI3-Kinase Inhibitor GDC-0941 in Combination With Paclitaxel, With and Without Bevacizumab or Trastuzumab, and With Letrozole, in Participants With Locally Recurrent or Metastatic Breast Cancer

Trial of Antimycobacterial Therapy in Sarcoidosis

Find Trials by Condition in Tennessee

Comparison of Nutritional Supplements in Preventing Weight Loss in Patients With Cancer

SU011248 in Patients With Metastatic Mucosal or Acral/Lentiginous Melanoma

Comparator Study Evaluating Patient Experience And Preference Of FFNS vs. FPNS

Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis

Efficacy and Safety of Multi-Instillations of Apaziquone in Patients With Non-Muscle Invasive Bladder Cancer

Cvac as Maintenance Treatment in Patients With Epithelial Ovarian Cancer in Complete Remission Following First-line Chemotherapy or Second-line Treatment

Safety and Preliminary Efficacy Study of V404 PDS in Uveitis

H7N9 Mix and Match With MF59 in Healthy Adults

Topical Sunscreen in Preventing Skin Rash in Patients Receiving Drugs Such as Erlotinib or Cetuximab for Cancer

Gefitinib With or Without Carboplatin and Paclitaxel in Treating Older Patients With Unresectable or Metastatic Non-Small Cell Lung Cancer

Temozolomide and Radiation Therapy in Treating Patients With Stage IV Malignant Melanoma With Measurable and Unresectable Cancer of the Central Nervous System

Irinotecan and Docetaxel in Treating Patients With Refractory Metastatic Breast Cancer

Fludarabine Plus Octreotide in Treating Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma

A First-in-Human, Double Blind, Single Dose Study in Healthy Subjects and Subjects With Mild Atopic Asthma.

Effect of Roflumilast on Lung Function in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Salmeterol: The EOS Study (BY217/M2-127)

Retapamulin Ointment in Healthy Adults Nasally Colonized With Staphylococcus Aureus

GLP-1 Receptor Agonist Lixisenatide (Morning or Evening) in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin

SinuSys Patency of Frontal Recess and Sphenoid Sinus Ostia Study