Clinical Trials in Tennessee

Showing 8341-8360 of 20,239 trials

Prospective Group-Matched Study With Belzupacap Sarotalocan (Bel-sar; AU-011) or Plaque Radiotherapy for Primary Indeterminate Lesions or Choroidal Melanoma (IL/ CM)

NCT05266430

This is a prospective multicenter, group-matched study of patients with primary indeterminate lesions or choroidal melanoma who receive treatment with belzupacap sarotalocan (bel-sar; AU-011) and patients who are planned to receive standard of care (SOC) treatment with plaque radiotherapy (plaque) to compare the visual outcomes of AU-011 and plaque radiotherapy.

Choroidal MelanomaIndeterminate Lesions

Aura Biosciences2 participantsStarted Apr 2022

Royal Oak, Michigan, United States • Portland, Oregon, United States • Greenville, South Carolina, United States +4 more locations

COMPLETEDPhase 129 miles

ADVM-022 Intravitreal Gene Therapy for Wet AMD

NCT03748784

ADVM-022 (AAV.7m8-aflibercept) is a gene therapy product developed for the treatment of neovascular (wet) age-related macular degeneration (wet AMD). Wet AMD is a serious condition and the leading cause of blindness in the elderly. The available therapies for treating wet AMD require life-long intravitreal (IVT) injections every 4-12 weeks to maintain efficacy. A one-time IVT administration of ADVM-022 has the potential to treat wet AMD by providing durable expression of therapeutic levels of intraocular anti-VEGF protein (aflibercept) and maintaining the vision of patients. ADVM-022 is designed to reduce the current treatment burden which often results in undertreatment and vision loss in patients with wet AMD receiving anti-VEGF therapy in clinical practice.

Adverum Biotechnologies, Inc.30 participantsStarted Nov 2018

Bakersfield, California, United States • Beverly Hills, California, United States • Golden, Colorado, United States +8 more locations

Prospective Group-Matched Study With Belzupacap Sarotalocan (Bel-sar; AU-011) or Plaque Radiotherapy for Primary Indeterminate Lesions or Choroidal Melanoma (IL/ CM)

ADVM-022 Intravitreal Gene Therapy for Wet AMD

Find Trials by Condition in Tennessee

Optimizing Psychosocial Treatment of Interstitial Cystitis/Bladder Pain Syndrome

A Study of Atezolizumab as Adjuvant Therapy in Participants With Renal Cell Carcinoma (RCC) at High Risk of Developing Metastasis Following Nephrectomy

A Study to Examine Past Estimated Glomerular Filtration Rate (eGFR) Slope as a Risk Marker for Rapid Kidney Function Decline in People With Chronic Kidney Disease

A Study to Evaluate Safety and Immunogenicity of One or Two Booster Vaccinations With H5N6 Influenza Vaccine in Adults Primed With H5N1 Influenza Vaccine or Unprimed

SPIRIT EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Endometriosis-Associated Pain

Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study (The APEX Study)

Zalutumumab in Non-curable Patients With SCCHN

Pharmacokinetics of Elinogrel in Healthy Volunteers and Patients With Mild, Moderate, and Severe Renal Impairment

Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal Cohort

Study of OT-101 in Treating Myopia

A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma

Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain

A Study of FT-7051 in Men With MCRPC

KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fusion

Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain

Novel Biomarker for Development of T2D

Bone Mineral Density in Postmenopausal Women at Increased Risk of Breast Cancer And Who Are Receiving Exemestane on MAP3

Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene