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Clinical Trials in Tennessee | 20,239 Studies Near You | Clareo Health

Clinical Trials LocationsTennessee

Clinical Trials in Tennessee

Discover 20,239 clinical trials near Tennessee. Find research studies in your area.

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Breast Cancer Lung Cancer Prostate Cancer Colorectal Cancer Melanoma Leukemia Lymphoma Pancreatic Cancer

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Showing 6241-6260 of 20,239 trials

COMPLETEDPhase 416 miles

Open-Label Study With Pimavanserin on Activities of Daily Living in Subjects With Parkinson's Disease Psychosis

NCT04292223

To assess the effect of pimavanserin on the activities of daily living in subjects with Parkinson's Disease Psychosis

Parkinson Disease Psychosis

ACADIA Pharmaceuticals Inc.29 participantsStarted Feb 2020

Scottsdale, Arizona, United States • Fullerton, California, United States • Miami, Florida, United States +15 more locations

COMPLETEDNA29 miles

Visualizing Vascular Mechanisms of Salt Sensitivity

NCT03696433

This study aims to assess the salt sensitive blood pressure response to dietary salt load compared with radiological markers of salt handling.

ObesityCardiovascular Risk FactorSalt; Excess

Vanderbilt University Medical Center19 participantsStarted Feb 2019

Nashville, Tennessee, United States

Find Trials by Condition in Tennessee

Breast Cancerin Tennessee Lung Cancerin Tennessee Prostate Cancerin Tennessee Colorectal Cancerin Tennessee Melanomain Tennessee Leukemiain Tennessee Lymphomain Tennessee Pancreatic Cancerin Tennessee Ovarian Cancerin Tennessee Brain Cancerin Tennessee

Data from ClinicalTrials.govTerms

Active Not RecruitingNA154 miles

PERSEVERE- A Trial to Evaluate AMDS in Acute DeBakey Type I Dissection

NCT05174767

Prospective, non-randomized, multicenter clinical investigation to assess the safety and effectiveness of AMDS in the treatment of patients with acute DeBakey type I dissection, with evidence of malperfusion, through open surgical repair.

Acute Aortic Dissection

Artivion Inc.115 participantsStarted May 2022

Birmingham, Alabama, United States • Los Angeles, California, United States • Palo Alto, California, United States +22 more locations

Active Not RecruitingPhase 2154 miles

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

NCT03709680

A study to learn about safety and find out maximum tolerable dose of palbociclib given in combination with chemotherapy (temozolomide with irinotecan or topotecan with cyclophosphamide) in children, adolescents and young adults with recurrent or refractory solid tumors (phase 1). Neuroblastoma tumor specific cohort to further evaluate antitumor activity of palbociclib in combination with topotecan and cyclophosphamide in children, adolescents, and young adults with recurrent or refractory neuroblastoma. Phase 2 to learn about the efficacy of palbociclib in combination with irinotecan and temozolomide when compared with irinotecan and temozolomide alone in the treatment of children, adolescents, and young adults with recurrent or refractory Ewing sarcoma (EWS).

Ewing SarcomaSolid TumorsRhabdoid Tumor+4 more

Pfizer128 participantsStarted May 2019

Birmingham, Alabama, United States • Phoenix, Arizona, United States • Long Beach, California, United States +98 more locations

COMPLETEDPhase 4154 miles

Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection

NCT03637660

This is a phase 4, randomized, open-label, multicenter trial to evaluate the efficacy of a single injected dose of Benzathine Penicillin G (BPG) 2.4 MU (Arm 1) compared to three successive weekly injected doses of BPG 2.4 MU (Arm 2) for treatment of early syphilis in human immunodeficiency virus (HIV)-infected and HIV-uninfected subjects. The study will enroll 560 adults (to achieve 420 evaluable subjects) aged 18 years or older with untreated early syphilis (primary, secondary, or early latent). It will be conducted at 9 sites in the US and last for 48 months with patient participation duration of 12 months. The primary objective is to compare the serological response to therapy in subjects with early (primary, secondary, or early latent) syphilis treated with Benzathine Penicillin G (BPG) 2.4 million units (MU) once or weekly for three successive weeks.

National Institute of Allergy and Infectious Diseases (NIAID)249 participantsStarted Oct 2018

Birmingham, Alabama, United States • Atlanta, Georgia, United States • Indianapolis, Indiana, United States +7 more locations

COMPLETEDPhase 2161 miles

A Study of the Safety of Oral Elsubrutinib Capsules and Oral Upadacitinib Tablets Given Alone or in Combination (ABBV-599) for Adult Participants With Moderately to Severely Active Systemic Lupus Erythematosus to Assess Change in Disease State

NCT04451772

Systemic Lupus Erythematosus (SLE) is an immune-mediated disease associated with inflammation of multiple organ systems. This study will evaluate how well elsubrutinib and upadacitinib given alone or as the ABBV-599 combination (elsubrutinib/upadacitinib) works within the body, in participants who completed study M19-130. This study will assess the change in disease symptoms. ABBV-599 is an investigational drug being developed for the treatment of Systemic Lupus Erythematosus (SLE). This study is "double-blinded", which means that neither the trial participants nor the study doctors will know who will be given which study drug. Study doctors put the participants into 1 of 4 groups called treatment arms. Each group receives a different treatment. Adult participants with a diagnosis of SLE will be enrolled. Around 260 participants will be enrolled in the study in approximately 100 sites worldwide. Participants will receive the following for up to 56 weeks: Participants will receive oral elsubrutinib capsules and/or oral upadacitinib tablets once daily for up to 56 weeks. Participants who were receiving elsubrutinib and/or upadacitnib in M19-130 will continue to receive the same treatment in this study. Participants who were receiving placebo in M19-130 will be re-randomized to one of the 2 combination treatment arms in this study. Arm 1: Elsubrutinib Dose A and Upadacitinib Dose A Arm 2: Elsubrutinib Dose A and Upadacitinib Dose B There may be higher burden for participants in this trial compared to their standard of care. Participants will attend monthly visits during the course of the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.

Systemic Lupus Erythematosus (SLE)

AbbVie185 participantsStarted Jul 2020

Phoenix, Arizona, United States • Beverly Hills, California, United States • Los Alamitos, California, United States +84 more locations

COMPLETEDNA178 miles

Safety Evaluation of the Advanced Hybrid Closed Loop (AHCL) System

NCT03959423

This study is a Safety Evaluation of the Advanced Hybrid Closed Loop (AHCL) System in Type 1 Adult and Pediatric Subjects.

Type 1 Diabetes Mellitus

Medtronic MiniMed, Inc.288 participantsStarted Jul 2019

Little Rock, Arkansas, United States • La Jolla, California, United States • Torrance, California, United States +14 more locations

Not Yet Recruiting193 miles

Nemaline Myopathy Clinical Research Network (NM-CTRN)

NCT06774703

The goal of this study is to establish a research network to help define the natural disease history and clinical outcome measures for Nemaline Myopathy (NM).

Nemaline Myopathy

Stanford University50 participantsStarted Jan 2025

Palo Alto, California, United States • Bethesda, Maryland, United States • Boston, Massachusetts, United States +3 more locations

COMPLETEDNA197 miles

Electronic Patient Reporting of Symptoms During Cancer Treatment

NCT03249090

The current study is designed to test nationally whether patients' outcomes and utilization of services can be improved through symptom monitoring via patient-reported outcomes between visits.

Metastatic Cancer

Alliance Foundation Trials, LLC.1,197 participantsStarted Oct 2017

Grand Junction, Colorado, United States • Lawrenceville, Georgia, United States • Harvey, Illinois, United States +42 more locations

Active Not Recruiting197 miles

The Syn-Sleep Study

NCT05757206

In collaboration with approximately 8 centers that specialize in iRBD we will recruit a total of 80 individuals for the study. All subjects will be enrolled into a 2-year longitudinal study where skin biopsies will be performed at 3 sites on each patient at 12-month intervals (baseline, year 1, year 2). Plasma blood collection will be performed at 12-month intervals (baseline, year 1, year 2). Detailed quantified examination, cognitive evaluation, medical history, and questionnaires will be performed at each visit. Additional biomarker, imaging and clinical information (if available) will be obtained for the purpose of determining phenoconversion to clinically apparent synucleinopathy. Subjects enrolled in the study will have baseline evaluations and follow up visits at 12 and 24 months to define any changes to clinical diagnosis (clinical phenoconversion). Skin biopsies will be repeated at the 12- and 24-month follow up visits to determine the rate of P-SYN accumulation over time and the rates of nerve fiber degeneration within punch skin biopsies.

REM Sleep Behavior Disorder (iRBD)

CND Life Sciences80 participantsStarted Sep 2022

Chandler, Arizona, United States • Phoenix, Arizona, United States • Scottsdale, Arizona, United States +5 more locations

COMPLETEDPhase 1/2250 miles

Safety, Tolerability, and Pharmacokinetics of Clesrovimab (MK-1654) in Infants (MK-1654-002)

NCT03524118

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and incidence of anti-drug antibodies (ADAs) of single ascending doses of clesrovimab in healthy pre-term (born at 29 to 35 weeks gestational age) and full-term (born at \>35 weeks gestational age) infants. Participants will be randomized into 1 of 4 dose escalation panels (Panels A to D); an additional panel (Panel E) of full-term infants will receive the same dose as Panel D. Key safety and tolerability variables will be reviewed after each dose panel prior to administering the next-highest dose.

Respiratory Tract InfectionRespiratory Syncytial Virus

Merck Sharp & Dohme LLC183 participantsStarted Sep 2018

Aurora, Colorado, United States • Homestead, Florida, United States • Miami, Florida, United States +31 more locations

COMPLETEDPhase 4260 miles

Metformin for Overweight & OBese ChILdren and Adolescents With BDS Treated With SGAs

NCT02515773

A prospective, large, pragmatic, randomized trial to study the impact of METFORMIN and healthy lifestyle intervention (LIFE) vs. LIFE alone on patient-centered outcomes of body weight, SGA-adherence and satisfaction, psychiatric symptom burden (e.g. mood/anxiety), and Quality of Life.

Bipolar Disorder

Melissa Delbello1,565 participantsStarted Dec 2015

Covington, Kentucky, United States • Neptune City, New Jersey, United States • Amityville, New York, United States +26 more locations

COMPLETEDPhase 2277 miles

Posaconazole (MK-5592) Intravenous and Oral in Children With Invasive Aspergillosis (IA) (MK-5592-104)

NCT04218851

This study will evaluate the safety, efficacy, and pharmacokinetics of posaconazole (POS) intravenous (IV) and oral formulations in pediatric participants 2 to \<18 years of age with invasive aspergillosis (IA).

Invasive Aspergillosis

Merck Sharp & Dohme LLC31 participantsStarted Jul 2020

Orange, California, United States • San Diego, California, United States • Chicago, Illinois, United States +26 more locations

COMPLETEDPhase 1/2354 miles

Uprosertib, Dabrafenib, and Trametinib in Treating Patients With Stage IIIC-IV Cancer

NCT01902173

This phase I/II trial studies the side effects and the best dose of uprosertib when given together with dabrafenib and trametinib and to see how well they work in treating patients with stage IIIC-IV cancer. Uprosertib, dabrafenib, and trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving uprosertib with dabrafenib and trametinib may be a better treatment for cancer.

Hematopoietic and Lymphoid Cell NeoplasmLocally Advanced Malignant Solid NeoplasmLocally Advanced Melanoma+6 more

National Cancer Institute (NCI)27 participantsStarted Oct 2013

Los Angeles, California, United States • Los Angeles, California, United States • San Francisco, California, United States +13 more locations

COMPLETEDPhase 2362 miles

Safety and Efficacy of XT-150 for Facet Joint Osteoarthritis Pain

NCT05196919

This is a Phase 2a safety and efficacy study of XT-150 in adult participants experiencing back pain due to inflammation of the facet joint, also known as facet joint osteoarthritis (FJOA), and who are eligible for intra articular glucocorticoid injection, or radiofrequency ablation of medial branches of the primary dorsal ramus of the exiting nerve root, which innervates the adjacent facet joints. Study drug will be administered at Day 0 and Day 90 by bilateral intra-articular (IA) injection into the facet capsule, at the affected spinal level (e.g. Lumbar \[L\]3-4, L4-5, or L5-Sacrum \[S\]1) as determined by imaging (e.g., Magnetic resonance imaging \[MRI\], Computed tomography \[CT\]), X-ray, etc.) and physical exam. Up to 72 participants will be randomized to placebo or one of two dose treatment groups (24 participants per treatment group). 1. 0.15 mg XT-150 (1.0 milliliter \[mL\] total delivered by two 0.5 mL injections) 2. 0.45 mg XT-150 (1.0 mL total delivered by two 0.5 mL injections) 3. Placebo (Sterile saline) (1.0 mL total delivered by two 0.5 mL injections)

Facet Joint PainBack PainInflammation

Xalud Therapeutics, Inc.75 participantsStarted Feb 2022

Napa, California, United States • Santa Monica, California, United States • Winston-Salem, North Carolina, United States

TERMINATEDPhase 2362 miles

Feasibility Study of Intraoperative Detection of Residual Cancer in Breast Cancer Patients

NCT04440982

This is a prospective, multi-center, randomized, clinical trial evaluating patients undergoing breast conserving surgery using the LUM Imaging System.

Breast CancerNeoadjuvant Therapy

Lumicell, Inc.98 participantsStarted Sep 2020

Palo Alto, California, United States • Clearwater, Florida, United States • Boston, Massachusetts, United States +3 more locations

Active Not RecruitingNA425 miles

Multi-center Clinical Study to Evaluate the C2 CryoBalloon Focal Ablation System

NCT02514525

To evaluate the efficacy and safety of the CryoBalloon Focal Ablation System for the treatment of previously-untreated ("treatment naïve") Barrett's Esophagus (BE)

Barrett Esophagus

Pentax Medical150 participantsStarted Mar 2016

Orange, California, United States • Sarasota, Florida, United States • Chicago, Illinois, United States +8 more locations

RECRUITINGPhase 1474 miles

Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies

NCT05488548

A Phase 1, first-in-human study of EP31670, a dual BET and CBP/p300 inhibitor in patients with targeted advanced solid tumors and Hematological Malignancies

Castrate Resistant Prostate CancerNUT CarcinomaChronic Myelomonocytic Leukemia+1 more

Epigenetix, Inc.75 participantsStarted Dec 2022

Phoenix, Arizona, United States • Jacksonville, Florida, United States • Boston, Massachusetts, United States +3 more locations

COMPLETEDPhase 4587 miles

Automated Insulin Delivery in Elderly With Type 1 Diabetes (AIDE T1D)

NCT04016662

A multi-center, randomized, crossover trial consisting of three sequential 12-week periods, with the HCL feature used during one period, the PLGS feature used during one period and SAP therapy (control) during one period. The crossover trial will be preceded by a run-in phase in which participants will receive training using the study devices (Dexcom G6 and Tandem t:slim X2 pump). After the last crossover period, participants will be given the opportunity to use study devices for an additional 12 weeks to assess preference of system use (PLGS, HCL or SAP) and associated characteristics, durability and safety in a more real-world setting with less frequent study contact.

Type 1 Diabetes Mellitus

Jaeb Center for Health Research82 participantsStarted Sep 2020

Orlando, Florida, United States • Rochester, Minnesota, United States • Syracuse, New York, United States +1 more locations

COMPLETEDPhase 1651 miles

Immunotherapy in Combination With Chemoradiation in Patients With Advanced Solid Tumors

NCT03509012

This is an open-label, multicenter, phase I study to evaluate the safety and tolerability of durvalumab ± tremelimumab in combination with chemoradiation in patients with advanced solid tumors

Carcinoma, Squamous Cell of Head and NeckCarcinoma, Non-Small-Cell LungSmall Cell Lung Carcinoma

AstraZeneca105 participantsStarted May 2018

Tucson, Arizona, United States • Aurora, Colorado, United States • Houston, Texas, United States +13 more locations

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