Clinical Trials in Tennessee

Showing 4421-4440 of 20,239 trials

Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor

NCT01734122

The purpose of this study is to determine the changes in quality of life and degree of tremor for patients with essential tremor or Parkinsonian tremor who are treated by stereotactic radiosurgery (SRS). This is a questionnaire-based study. Please see Detailed Description below for more information.

TremorEssential TremorParkinson Disease+2 more

Vanderbilt University Medical Center60 participantsStarted Feb 2013

Nashville, Tennessee, United States

COMPLETEDPhase 129 miles

Phase 1a/1b Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors

NCT04344795

This is a first-in-human Phase 1a/1b, multicenter, open-label, dose-escalation, dose and schedule optimization, and expansion study of TPST-1495 as a single agent and in combination with pembrolizumab to determine its maximum tolerated dose (MTD) and or recommended Phase 2 dose (RP2D), safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary anti-tumor activity in subjects with advanced solid tumors. Subjects with all histologic types of solid tumors are eligible for the escalation and dose-finding portions of the study. However, the preferred tumor types for enrollment are colorectal cancer (CRC), non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head and neck (SCCHN), urothelial cancer, endometrial cancer, and gastroesophageal junction (GEJ) or gastric adenocarcinoma. Enrollment in the expansion cohorts is limited to the following tumor types: endometrial, SCCHN, CRC, and a basket cohort in subjects selected for an activating mutation in PIK3Ca.

Solid TumorColorectal CancerNon Small Cell Lung Cancer+6 more

Tempest Therapeutics89 participantsStarted May 2020

Aurora, Colorado, United States • Baltimore, Maryland, United States • Springfield, Massachusetts, United States +8 more locations

Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor

Phase 1a/1b Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors

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Periprosthetic Fracture Registry (PPFx)

OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages

Co-Use of Opioid Medications and Alcohol Prevention Study

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)

A Study of an Investigational Flu Seasonal/SARS-CoV-2 Combination Vaccine in Adults

Tailored vs. Anatomical Ablation Strategy for Persistent Atrial Fibrillation

A Study Comparing Upadacitinib (ABT-494) to Placebo in Participants With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Biologic Disease Modifying Anti-Rheumatic Drug

A Study Comparing ATB200/AT2221 With Alglucosidase Alfa/Placebo in Adult Subjects With Late-onset Pompe Disease

Study to Evaluate the Safety and Efficacy of Pegvaliase in Adolescents (Ages 12-17) With Phenylketonuria

Study of the TearCare System in Dry Eye Disease

A Study of Brigatinib Compared to Alectinib in Adults With Non-Small-Cell Lung Cancer

A Study of ASP2215 (Gilteritinib) by Itself, ASP2215 Combined With Azacitidine or Azacitidine by Itself to Treat Adult Patients Who Have Recently Been Diagnosed With Acute Myeloid Leukemia With a FLT3 Gene Mutation and Who Cannot Receive Standard Chemotherapy

Clinical Utility of a PCR Compared to Culture and Sensitivity Testing for the Management of cUTI in Adults.

First-in-human Single Agent Study of SAR442085 in Relapsed or Refractory Multiple Myeloma

PROmotion of COVID-19 BOOSTer VA(X)Ccination in the Emergency Department - PROBOOSTVAXED

Study of Lademirsen (SAR339375) in Patients With Alport Syndrome

Use of Stromal Vascular Fraction in Multiple Sclerosis