Clinical Trials in Tennessee

Showing 4001-4020 of 20,239 trials

Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms

NCT05142267

The purpose of this study is to see how stress influences the effects of opioid pain medications often used to help relieve back pain. The study will help to learn more about how high stress levels could increase risk for pain medication misuse.

Opioid Use DisorderBack PainStress

Vanderbilt University Medical Center120 participantsStarted Mar 2022

Nashville, Tennessee, United States

Active Not RecruitingPhase 1/229 miles

Salt-Sensitivity and Immunity Cell Activation

NCT03753204

Salt-sensitive hypertension affects nearly 50% of the hypertensive and 25% of the normotensive population, and strong evidence indicates that reducing salt intake decreases blood pressure and cardiovascular events. The precise mechanisms of how dietary salt contributes to blood pressure elevation, renal injury, and cardiovascular disease remains unclear. Our data indicated that monocytes exhibit salt sensitivity, and the investigators hypothesize that of salt sensitivity of these and similar immune cells correlate with the hypertensive response to salt intake. Currently, the research tools for diagnosing salt-sensitivity are costly, time consuming and laborious. In this study the investigators will identify monocyte salt-sensitivity as a marker of salt-sensitive hypertension.

High Blood PressureSalt; ExcessInflammation

Vanderbilt University Medical Center20 participantsStarted Sep 2021

Nashville, Tennessee, United States

Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms

Salt-Sensitivity and Immunity Cell Activation

Find Trials by Condition in Tennessee

A Study of ZW171 in Participants With Advanced or Metastatic Mesothelin-expressing Cancers

First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)

Personalized Therapy Study - HFRS (TriageHF) Post Approval Study

Open-Label Safety and Tolerability Study of INCB057643 in Subjects With Advanced Malignancies

A Study to Evaluate the Long-term Safety and Tolerability of Lucerastat in Adult Subjects With Fabry Disease

Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)

A Study to Evaluate Early Treatment Outcomes With Miebo™ in Subjects With Dry Eye Disease

A Study of Sovilnesib in Subjects With Ovarian Cancer

A Phase 2 Study to Evaluate the Safety, Tolerability, and Immune Response of AFX3772 Vaccine in Healthy Infants

PMT for MDRO Decolonization

GRAVITAS-119: Itacitinib in Combination With Calcineurin Inhibitor-Based Interventions for the Prophylaxis of Graft-Versus Host Disease

Study of Daxdilimab (HZN-7734) in Participants With Moderate-to-Severe Primary Discoid Lupus Erythematosus

Nonhealing Diabetic Foot Ulcers Treated With Standard of Care (SOC) Alone or Standard of Care and Amnion-Intermediate-Chorion (AIC)

A Study of Multiple Doses of Nusinersen (ISIS 396443) Delivered to Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy

Hearing Impairment, Strategies and Outcomes in VA Emergency Departments

Gilteritinib for the Treatment of ALK NSCLC

Study of Fordadistrogene Movaparvovec in Early Stage Duchenne Muscular Dystrophy

Artacent Amniotic Tissue for Treatment of Chronic Lower Extremity Diabetic Ulcers.