Clinical Trials in Tennessee

Showing 2521-2540 of 17,345 trials

CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease

NCT05422534

Frailty and sarcopenia are modifiable risk factors for morbidity and mortality in patients with ESRD. Exercise is the recommended intervention to prevent frailty and sarcopenia, however, many clinical trials have shown limited clinical improvement in muscle mass and physical function. We propose that mitochondrial dysfunction is one of the deterrents to the effectiveness of the exercise. We plan to evaluate the additive effect of HIIT and CoQ10, a mitochondrial-targeted therapy, on mitochondrial function and physical performance. Understanding the interplay among CoQ10, exercise, and mitochondrial function will identify novel mechanisms to improve the efficiency of exercise. This will also serve to prevent frailty, sarcopenia, and muscle dysfunction in patients with ESRD.

End Stage Renal Disease

Vanderbilt University Medical Center156 participantsStarted Jun 2023

Sacramento, California, United States • Nashville, Tennessee, United States

COMPLETED29 miles

A Study of Suboptimally Controlled Participants Previously Taking Oral or Infusion DMDs for RMS (MASTER-2)

NCT03933202

To evaluate the effectiveness, safety and Patient-Reported Outcomes (PROs) of cladribine tablets in participants with RMS including relapsing-remitting multiple sclerosis (RRMS) and active secondary progressive multiple sclerosis (aSPMS), who transition to cladribine tablets after suboptimal response to any oral or infusion Disease-Modifying Drugs (DMDs) approved in the United States (US) for RMS in a real-world-setting.

Multiple Sclerosis

EMD Serono Research & Development Institute, Inc.291 participantsStarted Jul 2019

Cullman, Alabama, United States • Mobile, Alabama, United States • Little Rock, Arkansas, United States +63 more locations

CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease

A Study of Suboptimally Controlled Participants Previously Taking Oral or Infusion DMDs for RMS (MASTER-2)

Find Trials by Condition in Tennessee

Mode of Ventilation During Critical Illness at Multiple Centers

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

Evaluate the Safety, Tolerability, Pharmacokinetic Profile, Efficacy of Bl-M11D1

A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer

Study Evaluating the Efficacy, Safety, and Tolerability of Switching to Long-acting Cabotegravir Plus Long-acting Rilpivirine From Current Antiretroviral Regimen in Virologically Suppressed HIV-1-infected Adults

Understanding the Long-term Impact of COVID on Children and Families

An Extension Study of RPC1063 as Therapy for Moderate to Severe Ulcerative Colitis

Dose Escalation and Expansion Study to Evaluate the Safety, PK, PD and Efficacy of ZE46-0134 in Adults With FLT3 Mutated or Spliceosome Mutated Relapsed or Refractory Acute Myeloid Leukemia

A Study of the Long-term Safety and Tolerability of an Investigational Drug in People With Schizophrenia.

A Phase I Study to Evaluate the Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients With Advanced Solid Tumors

Sirolimus Coated BALloon Versus Standard Balloon Angioplasty in The Treatment of Below The Knee Arterial Disease

A Study of Radiation Dosimetry, Safety, and Tolerability of Extended Lutetium (177Lu) Vipivotide Tetraxetan Treatment in Chemo-naïve Adults With Metastatic Castration-resistant Prostate Cancer: RADIOpharmaceutical DOSimetry Evaluation (RADIODOSE) Study

Randomized Phase II Trial of Targeted Radiation With no Castration for Mcrpc

Training for Urinary Leakage Improvement After Pregnancy

Single Arm Trial of Menstrual Cups Among Economically Vulnerable Women to Reduce Bacterial Vaginosis and STIs

Safe Treatment for Emergency Presentation for Suicidal Ideation and Behavior in Youth

Study of NXP900 With Osimertinib in Subjects With Advanced, EGFR-Mutated Non-Small Cell Lung Cancer

Patient Satisfaction With Appearance, Scar Outcome and Quality of Life After Skin Cancer Surgery