Clinical Trials in Seattle

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AMD 3100 for Treatment of Myelokathexis

NCT01058993

This is an initial study to determine if CXCR4 inhibitor AMD 3100 or plerixafor may be a potential treatment for neutropenia due to CXCR4 mutations, the myelokathexis or WHIM (warts, hypogammaglobulinemia, immunodeficiency and myelokathexis) syndrome. This is the initial study of this concept and will involve up to 6 patients to receive increasing doses of plerixafor administered subcutaneously or on an alternate day basis. It is unknown if these patients will be highly sensitive to a blockade of CXCR4 activity and release more white blood cells than normal volunteers or cancer patients given the same dose of this drug. Therefore doses will begin at a level 12 fold less than currently used to mobilize stem cells and will be increased stepwise to achieve an acceptable circulating level of neutrophils.

Neutropenia

University of Washington6 participantsStarted Oct 2010

Seattle, Washington, United States

COMPLETEDPhase 2< 1 mile

S0101 Gemcitabine and Irinotecan in Treating Patients With Metastatic or Recurrent Cancer of the Esophagus

NCT00012363

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating patients who have metastatic or recurrent cancer of the esophagus.

Esophageal CancerGastric Cancer

SWOG Cancer Research Network61 participantsStarted Apr 2001

Mobile, Alabama, United States • Phoenix, Arizona, United States • Phoenix, Arizona, United States +93 more locations

AMD 3100 for Treatment of Myelokathexis

S0101 Gemcitabine and Irinotecan in Treating Patients With Metastatic or Recurrent Cancer of the Esophagus

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S9720 Combination Chemotherapy in Treating Patients With Metastatic, Recurrent, or Refractory Endometrial Cancer

A 6 Month Safety and Efficacy Study of Once Daily Ciclesonide Hydrofluoroalkane (HFA) in the Treatment of Perennial Allergic Rhinitis (PAR) in Subjects 12 Years and Older

Evaluation of Risk Minimization, Assessment and Outcomes in Patients With Chronic Pain Taking Avinza

Standard of Care (SOC) With or Without CTS-1027 in Hepatitis C (HCV) Null-Responders

Study of Subclinical Viral Infection

Study of CP-675,206 in Refractory Melanoma

YM598 Added to Mitoxantrone/Prednisone to Control Pain in Metastatic Prostate Cancer Patients No Longer Responding to Hormone Therapy

Bicalutamide (Casodex™) Versus Placebo in Patients With Early Prostate Cancer

TBTC Study 23C: Pharmacokinetics of Intermittent Rifabutin and Isoniazid With Daily Efavirenz

Safety and Effectiveness Study of the Ensure Medical Vascular Closure Device

Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee

S9923 R115777 in Treating Patients With Advanced Colorectal Cancer

A Study to Determine if Technosphere® Inhalation Powder (FDKP) Causes ECG Changes (QTc) Following the Medication's Inhaled Administration.

A Study of the In-Space Device for Treatment of Moderate Spinal Stenosis

Study On Bioavailability And Pharmacokinetics Of Various Doses Of Testosterone Administered With And Without Dutasteride

Biomarker Sub Study of the Compression Stockings to Prevent the Post-Thrombotic Syndrome (SOX) Trial

A Randomized Study to Evaluate FK962 in Subjects With Mild to Moderate Alzheimer's Disease

Safety and Efficacy Trial With Zoledronic Acid for the Treatment of Paget's Disease of Bone, Including an Extended Observation Period