Clinical Trials in Seattle

Showing 5961-5980 of 9,312 trials

Effects of High Flow Nasal Cannula on Deadspace Reduction and Regional Distribution of Ventilation

NCT02460653

1. To determine the lowest nasal cannula flow rate in which upper airway deadspace is reduced. Hypothesis - The lowest flow rate of high flow nasal cannula (HFNC) will reduce upper airway (extrathoracic) deadspace and improve respiratory efficiency by reducing transcutaneous CO2 and/or lower respiratory rate. 2. To determine the lowest nasal cannula flow rate in which regional distribution (as defined by EIT) of ventilation changes. Hypothesis - Moderate to high flow rates will create positive pressure that leads to improved regional distribution of ventilation.

Respiratory InsufficiencyHypoxia

Boston Children's Hospital40 participantsStarted May 2015

Boston, Massachusetts, United States • Seattle, Washington, United States

COMPLETEDPhase 1/2< 1 mile

Safety/Tolerability Study of Arikayce™ in Cystic Fibrosis Patients With Chronic Infection Due to Pseudomonas Aeruginosa

NCT00558844

This is a study to determine the safety and tolerability of 28 days of daily dosing of 560 mg of Arikayce™ versus placebo and daily dosing of 70 mg and 140 mg of Arikayce™ versus placebo in patients who have Cystic fibrosis (CF) and chronic infection due to pseudomonas aeruginosa.

Cystic Fibrosis

Insmed Incorporated41 participantsStarted Jan 2008

Birmingham, Alabama, United States • Los Angeles, California, United States • Miami, Florida, United States +16 more locations

Effects of High Flow Nasal Cannula on Deadspace Reduction and Regional Distribution of Ventilation

Safety/Tolerability Study of Arikayce™ in Cystic Fibrosis Patients With Chronic Infection Due to Pseudomonas Aeruginosa

Find Trials by Condition in Seattle

Gabapentin in Reducing the Need for Pain Medication in Patients With Bladder Cancer Undergoing Radical Cystectomy

Nexavar-Tarceva Combination Therapy for First Line Treatment of Patients Diagnosed With Hepatocellular Carcinoma

A Dose-Finding Study of Vedolizumab for Treatment of Steroid-Refractory Acute Intestinal Graft-Versus-Host Disease (GvHD) in Participants Who Have Undergone Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT)

Harm Reduction for Tobacco Smoking With Support of Tobacco-Replacing Electronic Nicotine Delivery Systems

Financial Navigation Program Intervention in Supporting Patients With Solid Tumors and Their Caregivers

Incidence and Severity of Residual Neuromuscular Blockade

Comparison Of 2 Doses Of Temsirolimus (Torisel) In Patients With Mantle Cell Lymphoma

Study to Determine Safety, Pharmacokinetics and Efficacy of GMI-1271 in Combination With Chemotherapy in AML

The Chimerix CMX001 Registry

Efficacy and Safety Study of CVT-301 In Parkinson's Disease Patients With OFF Episodes

Trending of Respiratory Rate Using the Nellcor™ Bedside Respiratory Patient Monitoring System

National Observational Study of Clinical Practices in Deceased Organ Donation

Randomized, Double-blind, Placebo-Controlled, Efficacy Study of a New Formulation of Phenylephrine HCL in the Common Cold

Phase II Trial of Erlotinib in Advanced Pancreatic Cancer

BKM120 as Second-line Therapy for Advanced Endometrial Cancer

Study to Evaluate Treatment of Dabrafenib Plus Trametinib in Subjects With BRAF Mutation-Positive Melanoma That Has Metastasized to the Brain

Phase 1 Safety and Tolerability of MEDI4736 in Combination With Dabrafenib and Trametinib or With Trametinib Alone

Randomized Safety Study of CVT-301 Compared to an Observational Control Group