Clinical Trials in Seattle

Showing 4921-4940 of 9,312 trials

Study of INT-747 as Monotherapy in Participants With Primary Biliary Cirrhosis (PBC)

NCT00570765

The primary hypothesis was that obeticholic acid (OCA) will cause a reduction in alkaline phosphatase levels in PBC participants, over a 12-week treatment period, as compared to placebo.

Liver Cirrhosis, Biliary

Intercept Pharmaceuticals60 participantsStarted Jan 2008

Detroit, Michigan, United States • Houston, Texas, United States • Richmond, Virginia, United States +18 more locations

COMPLETEDPhase 2< 1 mile

Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia

NCT00860574

This phase II trial is studying how well giving treosulfan together with fludarabine phosphate and total-body irradiation followed by donor stem cell transplant works in treating patients with high-risk acute myeloid leukemia, myelodysplastic syndrome, acute lymphoblastic leukemia. Giving chemotherapy, such as treosulfan and fludarabine phosphate, and total-body irradiation before a donor bone marrow or peripheral blood stem cell transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving tacrolimus and methotrexate before and after transplant may stop this from happening

Accelerated Phase Chronic Myelogenous LeukemiaAdult Acute Lymphoblastic Leukemia in RemissionAdult Acute Myeloid Leukemia in Remission+21 more

Fred Hutchinson Cancer Center96 participantsStarted Feb 2009

Denver, Colorado, United States • Portland, Oregon, United States • Seattle, Washington, United States

Study of INT-747 as Monotherapy in Participants With Primary Biliary Cirrhosis (PBC)

Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia

Find Trials by Condition in Seattle

Regimen Optimization Study

Orthotics in Ambulatory Cerebral Palsy

Veterans Nature Therapy (Vet Hike)

Chemotherapy Based on Positron Emission Tomography Scan in Treating Patients With Stage I or Stage II Hodgkin Lymphoma

Rufinamide Given as Adjunctive Therapy in Participants With Refractory Partial Seizures

Exploratory Study of SPD489 in Adults With Major Depressive Disorder (MDD) as Augmentation Therapy to an Antidepressant

SPD489 Adult Major Depressive Disorder (MDD) Open-label Safety and Tolerability Rollover Extension Study

Vyvanse Adolescent Open-Label Safety and Efficacy Extension Study

Efficacy and Safety of SPD503 in Combination With Psychostimulants

Comparison of Lisdexamfetamine Dimesylate With Atomoxetine HCl in Attention-Deficit/Hyperactivity Disorder (ADHD) Subjects With an Inadequate Response to Methylphenidate

A 6-week Dose Ranging Study of CHF 5259 pMDI in Subjects With Chronic Obstructive Pulmonary Disease

Guanfacine Immediate-release Electrocardiogram Results (QTc) Study

Efficacy and Safety Trial of Flexible Doses of Oral Ziprasidone in Children and Adolescents With Bipolar I Disorder

Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus Not Currently Treated With Antidiabetic Therapy

A Pragmatic Randomized Control Trial Comparing Models of Care in the Management of Prescription Opioid Misuse

Study of DPX-Survivac Therapy in Patients With Recurrent Ovarian Cancer

Treatment of Adenoviral Conjunctivitis With SHP640 Compared to Povidone-iodine (PVP-I) and Placebo

Prevention of Recurrence of Diverticulitis