Clinical Trials in San Francisco

Showing 12321-12340 of 12,991 trials

A Safety Study of XL019 in Adults With Myelofibrosis

NCT00522574

The purpose of this study is to evaluate the safety and tolerability of XL019 in adults with myelofibrosis. XL019 is a selective inhibitor of the cytoplasmic tyrosine kinase JAK2. JAK2 is activated by cytokine and growth factor receptors and phosphorylates members of the STAT family of inducible transcription factors. Activation of the JAK/STAT pathway promotes cell growth and survival, and is a common feature of human tumors. JAK2 is activated by mutation in the majority of patients with myelofibrosis, polycythemia vera and essential thrombocytosis and appears to drive the inappropriate growth of blood cells in these conditions.

Myeloproliferative DisordersMyelofibrosisPolycythemia Vera+1 more

Exelixis100 participantsStarted Aug 2007

San Francisco, California, United States • Tampa, Florida, United States • Boston, Massachusetts, United States +2 more locations

COMPLETEDPhase 4< 1 mile

The Evaluation of the Efficacy and Safety of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment (MCI)

NCT00293176

To investigate the efficacy and safety of donepezil in individuals with mild cognitive impairment on measures of cognition, global function and behavior.

Memory Loss

Eisai Inc.821 participantsStarted Dec 2003

Albaster, Alabama, United States • Mesa, Arizona, United States • Peoria, Arizona, United States +51 more locations

A Safety Study of XL019 in Adults With Myelofibrosis

The Evaluation of the Efficacy and Safety of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment (MCI)

Find Trials by Condition in San Francisco

Modafinil-Alcohol Interactions in Healthy Volunteers

Do Community Cancer Support Groups Reduce Physiological Stress in Women With Primary Breast Cancer?

A Randomized, Controlled Study of Intravenous Ganciclovir Therapy for Peripheral Cytomegalovirus Retinitis in Patients With AIDS

A Phase II Efficacy Study Comparing 2',3'-Dideoxyinosine (ddI) (BMY-40900) and Zidovudine Therapy of Patients With HIV Infection Who Have Been on Long Term Zidovudine Treatment

Effects on the Immune System of Anti-HIV Drugs in Patients Recently Infected With HIV

Screening Protocol To Determine Eligibility For Studies Of The Chemokine Coreceptor 5 (CCR5) Antagonist GW873140

Comparison of ddI Versus Zidovudine in HIV-Infected Patients

An Efficacy Study of 2',3'-Dideoxyinosine (ddI) (BMY-40900) Administered Orally Twice Daily to Zidovudine Intolerant Patients With AIDS or AIDS-Related Complex

Phase II Study of Oxaliplatin and Taxotere in Metastatic Bladder Cancer

Brain Oxygenation and Hemodynamics During Sleep in Obstructive Sleep Apnea Sufferers

Protect II, A Prospective, Multicenter Randomized Controlled Trial

Cetrorelix Pamoate IM Regimens in Patients With Symptomatic Benign Prostatic Hyperplasia (BPH)

Effect of High and Low Sodium Diets on Blood Pressure in Hypertensive Patients Treated With Aliskiren

An Effectiveness And Safety Study Of PD 0299685 For The Treatment Of Symptoms Associated With Interstitial Cystitis

Effects of Zoledronic Acid and Raloxifene on Bone Turnover Markers in Postmenopausal Women With Low Bone Mineral Density

Investigating Efficacy and Safety of Two Degarelix Three-Month Dosing Regimens in Patients With Prostate Cancer Requiring Androgen Ablation Therapy

DPBRN Prevalence of Questionable Occlusal Caries Lesions

The Clinic Treatment Project