Clinical Trials in San Francisco

Showing 10281-10300 of 12,991 trials

Retrospective Multicenter Study to Determine 4-Year Clinical Outcomes in Subjects Previously Enrolled in the CTOT-05 Study

NCT02255123

This study is a multicenter, non-randomized, retrospective study to collect long term (4 years post-transplant) clinical outcome data on subjects previously enrolled in the CTOT-05 study (NCT00466804) to evaluate participant and graft survival.

Cardiac Transplantation

National Institute of Allergy and Infectious Diseases (NIAID)178 participantsStarted Oct 2014

San Francisco, California, United States • Chicago, Illinois, United States • Maywood, Illinois, United States +9 more locations

COMPLETEDPhase 2< 1 mile

A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis

NCT01173497

The purpose of the study is to investigate the response rate for triple negative breast cancer patients with brain metastasis when INIPARIB is used in combination with irinotecan. Based on data generated by BiPar/Sanofi, it is concluded that iniparib does not possess characteristics typical of the PARP inhibitor class. The exact mechanism has not yet been fully elucidated, however based on experiments on tumor cells performed in the laboratory, iniparib is a novel investigational anti-cancer agent that induces gamma-H2AX (a marker of DNA damage) in tumor cell lines, induces cell cycle arrest in the G2/M phase in tumor cell lines, and potentiates the cell cycle effects of DNA damaging modalities in tumor cell lines. Investigations into potential targets of iniparib and its metabolites are ongoing.

Estrogen Receptor Negative (ER-Negative) Breast CancerProgesterone Receptor Negative (PR-Negative) Breast CancerHuman Epidermal Growth Factor Receptor 2 Negative (HER2-Negative) Breast Cancer+1 more

Sanofi44 participantsStarted Jul 2010

Birmingham, Alabama, United States • San Francisco, California, United States • Washington D.C., District of Columbia, United States +10 more locations

Retrospective Multicenter Study to Determine 4-Year Clinical Outcomes in Subjects Previously Enrolled in the CTOT-05 Study

A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis

Find Trials by Condition in San Francisco

Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers

Evaluation of the Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures

Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole

An Observational Study on Long-Term Persistence of Resistant Mutations And Durability of Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Direct Acting Antiviral (DAA)- Containing Regimens

Study of Intravenous NRX-1074 in Patients With Major Depressive Disorder

Safety and Efficacy Study of Ramelteon (TAK-375) Tablets for Sublingual Administration (SL) in Adults With Bipolar 1 Disorder

Open Label Extension of Prior TERMS Study to Treat Relapsing Forms of Multiple Sclerosis

Trial of Gemcitabine/Carboplatin With or Without Iniparib (SAR240550) (a PARP1 Inhibitor) in Subjects With Previously Untreated Stage IV Squamous Non-Small-Cell Lung Cancer (NSCLC)

Atacicept Phase 2/3 in Generalized Systemic Lupus Erythematosus (APRIL-SLE)

Randomized Controlled Study of Donepezil in Fragile X Syndrome

Efficacy, Safety And Tolerability Study Of RN6G In Subjects With Geographic Atrophy Secondary to Age-related Macular Degeneration

Safety and Efficacy of Eslicarbazepine Acetate Monotherapy in Subjects With Partial Epilepsy Not Well Controlled by Current Antiepileptic Drugs

Evaluation of Weekly Idrabiotaparinux Sodium Versus Oral Adjusted-dose Warfarin to Prevent Stroke and Systemic Thromboembolic Events in Patients With Atrial Fibrillation

Bosutinib For Autosomal Dominant Polycystic Kidney Disease

Evaluation of Efficacy and Safety for Single Dose of E004 in Children With Asthma

Efficacy and Safety of GLYX-13 in Subjects With Inadequate/Partial Response to Antidepressants

A Long-Term Safety and Efficacy Study of Eszopiclone in Elderly With Primary Chronic Insomnia

Safety and Efficacy of BKM120 in Patients With Metastatic Non-small Cell Lung Cancer