Clinical Trials in San Francisco

Showing 3221-3240 of 11,161 trials

Pilot Study of (MR) Imaging with Pyruvate (13C) to Detect High Grade Prostate Cancer

NCT02526368

This pilot clinical trial studies how well magnetic resonance spectroscopic imaging (MRSI) with hyperpolarized carbon 13 (13C) pyruvate alone or in combination with 13C 15N2 Urea works in finding prostate cancer that exhibits poorly differentiated or undifferentiated cells (high-grade) and that is restricted to the site of origin, without evidence of spread (localized) in patients undergoing radical prostatectomy. Diagnostic procedures, such as MRSI with hyperpolarized carbon (13C) pyruvate, may aid in the diagnosis of prostate cancer and in discriminating high-grade from low-grade prostate cancer and benign adjacent prostate tissue

Prostate CancerLocalized Prostate Carcinoma

Ivan de Kouchkovsky, MD80 participantsStarted Mar 2016

San Francisco, California, United States

COMPLETEDPhase 1/2< 1 mile

Trial of H3B-6545, in Women With Locally Advanced or Metastatic Estrogen Receptor-positive, HER2 Negative Breast Cancer

NCT03250676

The primary purpose of phase 1 portion of this study is to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of H3B-6545 in women with locally advanced or metastatic estrogen receptor (ER)-positive, human epidermal growth factor 2 (HER2)-negative breast cancer. The primary purpose of phase 2 portion of this study is to estimate the efficacy of H3B-6545 in terms of best overall response rate, duration of response (DoR), clinical benefit rate (CBR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS) in all participants with ER-positive, HER2-negative breast cancer and in those with and without ER alpha mutation (including a clonal estrogen receptor 1 gene \[ESR1\] Y537S mutation).

Breast NeoplasmsBreast CancerEstrogen-receptor Positive Breast Cancer+5 more

Eisai Inc.151 participantsStarted Aug 2017

Goodyear, Arizona, United States • Los Angeles, California, United States • San Francisco, California, United States +36 more locations

Pilot Study of (MR) Imaging with Pyruvate (13C) to Detect High Grade Prostate Cancer

Trial of H3B-6545, in Women With Locally Advanced or Metastatic Estrogen Receptor-positive, HER2 Negative Breast Cancer

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177Lu-PSMA-617 and Pembrolizumab in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

Trial to Assess Safety and Efficacy of MOR202 in Anti-PLA2R + Membranous Nephropathy (aMN)

Spermatogonial Differentiation Via Testicular Organoid

In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes

Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis

[Study Evaluating the Efficacy and Safety of a Digital Therapeutic as an Adjunct to TAU in Postpartum Depression]

Therapeutic Effects of Electrical Vestibular Stimulation (EVS) on Balance and Gait

FUnctional diagnoSIs of corONary Stenosis (FUSION)

Long-term Follow-up of Participants With Cerebral Adrenoleukodystrophy Who Were Treated With Lenti-D Drug Product

Persona Partial Knee Clinical Outcomes Study

An Observational Study of Presentation, Treatment Patterns, and Outcomes in Multiple Myeloma Participants

A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Cancer

Repeat of: A Study to Evaluate Efficacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With Fibromyalgia

Dermal Allograft Augmentation of Large and Massive Rotator Cuff Tears

Comparison of Chronocort Versus Standard Hydrocortisone Replacement Therapy in Participants Aged 16 Years and Over With Congenital Adrenal Hyperplasia

Radium-223 Dichloride and Abiraterone Acetate Compared to Placebo and Abiraterone Acetate for Men With Cancer of the Prostate When Medical or Surgical Castration Does Not Work and When the Cancer Has Spread to the Bone, Has Not Been Treated With Chemotherapy and is Causing no or Only Mild Symptoms

Counseling for Harm Reduction and Retention in Medication-assisted Treatment - Cherokee Nation

TGRX-678 US Phase I for Subjects with Refractory or Advanced Chronic Myelogenous Leukemia