Clinical Trials in Pittsburgh

Showing 13881-13900 of 21,047 trials

Trial of Dasatinib (Sprycel®) in Subjects With Hormone-refractory Prostate Cancer

NCT00570700

The purpose of this research study is to find out if a new anti-cancer drug, dasatinib (Sprycel®), previously approved for treatment of some forms of leukemia, will be safe and helpful in treating patients with hormone-refractory prostate cancer. This is a research study because the study drug, dasatinib (Sprycel®), has not been evaluated for safety or effectiveness in patients with hormone-refractory prostate cancer. The drug is approved by the Food and Drug Administration for treatment of some forms of leukemia; thus, dasatinib (Sprycel®) is not an investigational drug. It has been given safely to hundreds of patients already. However its safety and usefulness in this study population (prostate cancer) is unknown. Subjects who agree to participate will take 150mg (3 pills) of dasatinib (Sprycel®) daily by mouth for as long as the drug benefits them. During this time, the subject will periodically return to the office for blood/urine tests, X-rays, imaging scans, and/or to complete questionnaires.

Hormone-refractory Prostate CancerAdenocarcinoma of the ProstateHormone-resistant Prostate Cancer+2 more

University of California, Irvine38 participantsStarted Jul 2007

Duarte, California, United States • Loma Linda, California, United States • Orange, California, United States +3 more locations

COMPLETEDPhase 2< 1 mile

Dose-Finding Study to Evaluate the Safety, Efficacy, & Tolerability of Multiple Doses of rAvPAL-PEG in Subjects With PKU

NCT00925054

The purpose of this study is to evaluate whether weekly injections of phenylalanine ammonia lyase (rAvPAL-PEG) can reduce blood phenylalanine concentrations in PKU subjects and whether repeated administration is safe.

Phenylketonuria

BioMarin Pharmaceutical40 participantsStarted Sep 2009

Aurora, Colorado, United States • Decatur, Georgia, United States • Chicago, Illinois, United States +8 more locations

Trial of Dasatinib (Sprycel®) in Subjects With Hormone-refractory Prostate Cancer

Dose-Finding Study to Evaluate the Safety, Efficacy, & Tolerability of Multiple Doses of rAvPAL-PEG in Subjects With PKU

Find Trials by Condition in Pittsburgh

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock

A Study to Assess the Pharmacokinetics of Ramucirumab (IMC-1121B) in Combination With FOLFIRI

A Phase II Study to Evaluate Safety and Efficacy of ALX-0061 in Subjects With Systemic Lupus Erythematosus

Clinical Study of Macitentan in Patients With Pulmonary Arterial Hypertension to Psychometrically Validate the PAH-SYMPACT Instrument

Eustachian Tube Growth and Development

Evaluate Risk/Benefit of Nab Paclitaxel in Combination With Gemcitabine and Carboplatin Compared to Gemcitabine and Carboplatin in Triple Negative Metastatic Breast Cancer (or Metastatic Triple Negative Breast Cancer)

Thyroid Therapy for Mild Thyroid Deficiency in Pregnancy

Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)

Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail

Irrigated Ablation System Evaluation for Atrial Fibrillation (AF)

Efficacy and Safety of SNX-5422 Added to an Established Dose of Ibrutinib in CLL

A Randomized, Open-Label, Parallel-Group, Multi-Center Study for the Evaluation of Efficacy and Safety of Edoxaban Monotherapy Versus Low Molecular Weight (LMW) Heparin/Warfarin in Subjects With Symptomatic Deep-Vein Thrombosis

Heart Outcomes Prevention and Evaluation 4

Sirolimus Before Surgery in Treating Patients With Advanced Localized Prostate Cancer

A Study to Assess the Safety of a Potential New Drug in Comparison to the Standard Practice of Dosing With Warfarin for Non-valvular Atrial Fibrillation

NuShield/Affinity for the Treatment of Neuropathic Diabetic Foot Ulcers

Assessment of Diagnostic Accuracy and Performance of Digital Breast Tomosynthesis Compared to Mammography (ADAPT)

Monitoring of Multiple Sclerosis (MS) Participants With the Use of Digital Technology (Smartphones and Smartwatches) - A Feasibility Study