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Clinical Trials in Pittsburgh | 21,047 Studies Near You | Clareo Health

Clinical Trials LocationsPittsburgh

Clinical Trials in Pittsburgh

Discover 21,047 clinical trials near Pittsburgh, Pennsylvania. Find research studies in your area.

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Showing 13761-13780 of 21,047 trials

COMPLETED46 miles

Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study

NCT03292003

The objective of this study is to estimate the safety and performance of Journey II BCS TKS.

Total Knee Arthroplasty

Smith & Nephew, Inc.1,694 participantsStarted Dec 2016

Aurora, Colorado, United States • Gulf Breeze, Florida, United States • Indianapolis, Indiana, United States +9 more locations

UNKNOWN55 miles

A Prospective Multicenter Post Approval Study of the ReShape™ Integrated Dual Balloon System in Obese Subjects

NCT02927665

The ReShape Post Approval Study is a prospective multicenter study of the ReShape(TM) Integrated Dual Balloon System in Obese Subjects.

ReShape Lifesciences186 participantsStarted Sep 2016

Dothan, Alabama, United States • Newark, Delaware, United States • Barrington, Illinois, United States +11 more locations

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Data from ClinicalTrials.govTerms

COMPLETEDPhase 277 miles

Alternative Dosing Strategy of Ruxolitinib in Patients With Myelofibrosis

NCT01445769

The purpose of this study was to evaluate the effect of an alternative dosing strategy of ruxolitinib in subjects with primary myelofibrosis (PMF), post-polycythemia vera-myelofibrosis (PPV-MF) and post essential thrombocythemia-myelofibrosis (PET-MF) in order to minimize the development of anemia and thrombocytopenia.

Primary MyelofibrosisPost-Polycythemia Vera MyelofibrosisPost-Essential Thrombocythemia Myelofibrosis

Incyte Corporation45 participantsStarted Sep 2011

Highland, California, United States • La Jolla, California, United States • Los Angeles, California, United States +18 more locations

TERMINATEDPhase 282 miles

Study to Assess Analgesic Efficacy and Safety of ASP3662 in Subjects With Painful Diabetic Peripheral Neuropathy

NCT02372578

The purpose of this study is to assess analgesic efficacy of ASP3662 relative to placebo in subjects with painful diabetic peripheral neuropathy (PDPN) as well as assess the safety and tolerability of ASP3662 relative to placebo. The analgesic effect is evaluated by measuring percent responders, change in daily worst pain score, change in average daily pain score, Patient Global Impression of Change (PGIC) and Clinical Global Impression of Change (CGIC).

Painful Diabetic Peripheral Neuropathy (PDPN)

Astellas Pharma Global Development, Inc.115 participantsStarted May 2015

Anniston, Alabama, United States • Phoenix, Arizona, United States • Fresno, California, United States +34 more locations

COMPLETEDPhase 2108 miles

Evaluation of ETC-1002 vs Placebo in Patients Receiving Ongoing Statin Therapy

NCT02072161

The purpose of this research study is to see how ETC-1002 is tolerated in the body and how ETC-1002 affects the levels of LDL-C (bad cholesterol) in patients receiving ongoing statin therapy.

Hypercholesterolemia

Esperion Therapeutics, Inc.133 participantsStarted Mar 2014

Muscle Shoals, Alabama, United States • Chandler, Arizona, United States • Chino, California, United States +37 more locations

TERMINATEDNA115 miles

Mechanical vs. Radiofrequency-Based Debridement in the Treatment of Articular Cartilage Lesions

NCT01803880

The purpose of this study is to evaluate changes in clinical and imaging outcomes following arthroscopic treatment of a single medial femoral chondral lesion plus partial medial meniscectomy by Radiofrequency-Based debridement or Mechanical Debridement in subjects ≥ eighteen (18) years of age.

Chondral Lesion Plus Partial Medial Meniscectomy

Smith & Nephew, Inc.148 participantsStarted Mar 2013

Tucson, Arizona, United States • Gulf Breeze, Florida, United States • Greenwood, Indiana, United States +4 more locations

TERMINATEDPhase 2115 miles

Safety and Efficacy of Simtuzumab (SIM, GS-6624) in Adults With Advanced Liver Fibrosis But Not Cirrhosis Secondary to Non-Alcoholic Steatohepatitis (NASH)

NCT01672866

The primary objective of this study is to evaluate whether SIM (formerly referred to as GS-6624) is effective at preventing the histologic progression of liver fibrosis and the clinical progression to cirrhosis in participants with NASH. It will consist of 2 phases: * Randomized Double-Blind Phase * Open-Label Phase (optional)

Liver Fibrosis Due to NASH

Gilead Sciences222 participantsStarted Dec 2012

Phoenix, Arizona, United States • Coronado, California, United States • San Diego, California, United States +65 more locations

TERMINATEDPhase 2115 miles

Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder

NCT02871427

This study seeks to evaluate the long-term safety and effectiveness of nelotanserin for the treatment of visual hallucinations (VHs) and Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with Lewy body dementia (LBD).

Lewy Body DementiaDementia With Lewy BodiesParkinson's Disease Dementia+2 more

Axovant Sciences Ltd.80 participantsStarted Oct 2016

Birmingham, Alabama, United States • Little Rock, Arkansas, United States • Boca Raton, Florida, United States +16 more locations

TERMINATEDPhase 3162 miles

Confirmatory Study of NeoCart in Knee Cartilage Repair

NCT01066702

This confirmatory study is a prospective randomized trial comparing the efficacy and safety of an autologous chondrocyte tissue implant (NeoCart) to the surgical intervention microfracture in the treatment of cartilage defects in the knee.

Articular Cartilage Defects in the Knee Joint

Histogenics Corporation245 participantsStarted May 2010

Tucson, Arizona, United States • La Mesa, California, United States • Orange, California, United States +28 more locations

COMPLETED162 miles

Patient Functioning and Well-being, Economic, and Clinical Impact of Hemophilia A and Its Treatment

NCT02396862

The purpose of the study is to improve the understanding of key patient reported outcomes such as quality of life as well as clinical outcomes in hemophilia A, in a global real world setting.

Bayer272 participantsStarted Dec 2015

Phoenix, Arizona, United States • Aurora, Colorado, United States • Washington D.C., District of Columbia, United States +7 more locations

COMPLETEDPhase 3162 miles

The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of Long De Novo Coronary Artery Lesions (PLATINUM LL)

NCT01500434

The purpose of this study is to evaluate the safety and effectiveness of the PROMUS Element™ Everolimus-Eluting Coronary Stent System for the treatment of patients with up to 2 de novo atherosclerotic coronary artery lesions. The lesions can be longer than average-sized.

Coronary Artery Disease

Boston Scientific Corporation102 participantsStarted Feb 2009

La Jolla, California, United States • Sacramento, California, United States • San Diego, California, United States +27 more locations

TERMINATEDPhase 2190 miles

Study to Examine the Safety and Efficacy of Pimavanserin for the Treatment of Agitation and Aggression in Alzheimer's Disease (SERENE)

NCT02992132

To evaluate the efficacy of pimavanserin compared with placebo in treatment of agitation and aggression after 12 weeks of treatment

Agitation and Aggression in Alzheimer's Disease

ACADIA Pharmaceuticals Inc.111 participantsStarted Nov 2016

Costa Mesa, California, United States • Fresno, California, United States • Fullerton, California, United States +53 more locations

COMPLETEDNA190 miles

Vitamin D Absorption in HIV Infected Young Adults Being Treated With Tenofovir Containing cART

NCT01751646

This is a 48 week randomized double-blind, placebo-controlled prospective cohort study of adolescents and young adults with HIV infection in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) who are currently being treated with cART that includes tenofovir disoproxil fumarate (TDF) as one component of the regimen that includes at least three Food and Drug Administration (FDA)-approved antiretroviral (ARV) drugs for at least 180 days.

University of North Carolina, Chapel Hill214 participantsStarted Oct 2012

Los Angeles, California, United States • Los Angeles, California, United States • Washington D.C., District of Columbia, United States +14 more locations

COMPLETED196 miles

Renal, Endocrine, and Bone Changes in Response to FTC/TDF in Uninfected Young Men Who Have Sex With Men (YMSM).

NCT01769469

This is a prospective observational cohort sub-study of subjects enrolled in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) 110 (NCT01772823) or ATN 113 (NCT01769456), which is a prospective interventional trial.

University of North Carolina, Chapel Hill101 participantsStarted Nov 2012

Los Angeles, California, United States • Aurora, Colorado, United States • Miami, Florida, United States +9 more locations

COMPLETEDPhase 2205 miles

Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary Cirrhosis

NCT01904058

The study is a randomized, double-blind, placebo-controlled, multicenter study. It is a 13-week Phase 2 study in adults with primary biliary cirrhosis designed to compare the effect of daily dosing with UDCA in combination with LUM001 or placebo.

PBCPrimary Biliary Cirrhosis

Mirum Pharmaceuticals, Inc.66 participantsStarted Aug 2013

La Jolla, California, United States • Sacramento, California, United States • Miami, Florida, United States +21 more locations

COMPLETEDPhase 2228 miles

Open Label Study to Evaluate Safety and Efficacy of LUM001 in Patients With Primary Sclerosing Cholangitis

NCT02061540

The study is an open-label study in adults with primary sclerosing cholangitis to evaluate the safety, tolerability, and effect of 14-weeks of daily dosing of LUM001.

Primary Sclerosing Cholangitis (PSC)

Mirum Pharmaceuticals, Inc.27 participantsStarted Mar 2014

La Jolla, California, United States • Sacramento, California, United States • Aurora, Colorado, United States +6 more locations

COMPLETED228 miles

FLU A+B Nasal Swab Clinical Study

NCT00636662

The purpose of this clinical study is to obtain clearance for the nasal swab sample type by demonstrating the performance characteristics of the FLU A+B Test versus standard laboratory culture for Influenza A and B viruses using nasal swab samples.

Response Biomedical Corp.800 participantsStarted Feb 2008

Chicago, Illinois, United States • St Louis, Missouri, United States • Winston-Salem, North Carolina, United States +2 more locations

TERMINATEDPhase 2232 miles

Open-label Extension Study to Assess Safety and Tolerability of LYC-30937-EC in Subjects With Active Ulcerative Colitis

NCT02764229

The purpose of this study is to allow subjects completing study LYC-30937-2001 the opportunity to receive LYC-30937-EC 25 mg.

Colitis, Ulcerative

Lycera Corp.112 participantsStarted Nov 2016

Little Rock, Arkansas, United States • Mission Hills, California, United States • Miami, Florida, United States +37 more locations

COMPLETEDPhase 2256 miles

Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency

NCT01054339

Assessment of the safety and efficacy of intramuscular (IM) administration of a recombinant adenoassociated virus (rAAV) alpha-1 antitrypsin (AAT) vector (rAAV1-CB-hAAT) in AAT-deficient adults at three dosage levels \[6.0 × 10e11, 1.9 × 10e12 and 6.0 × 10e12 vector genome particles (vg) per kg body weight\]. Funding Sources - The FDA Office of Orphan Products Development and NIH National Heart, Lung, and Blood Institute

Alpha-1 Antitrypsin Deficiency

Beacon Therapeutics9 participantsStarted Jun 2010

Denver, Colorado, United States • Worcester, Massachusetts, United States • Cincinnati, Ohio, United States +1 more locations

COMPLETEDPhase 2481 miles

A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor

NCT01396148

Children and young adults with gastrointestinal stromal tumors (GIST) will be treated with sunitinib. The safety (including pharmacokinetics) and tolerability of sunitinib will be studied in these patients. In addition, tumor responses and overall survival will be assessed.

Gastrointestinal Stromal Tumors

Pfizer6 participantsStarted Jun 2012

Los Angeles, California, United States • Boston, Massachusetts, United States • Boston, Massachusetts, United States +6 more locations

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