Clinical Trials in Pittsburgh

Showing 13541-13560 of 21,047 trials

Role of NGS-based ThyroSeq Panel in Cancer Diagnosis in Thyroid Nodules

NCT02352766

Recently, targeted next generation sequencing (NGS) platforms have been introduced that allow inexpensive testing for hundreds of mutational hotspots at the same time. A number of additional mutational markers in thyroid cancer have been identified. Highly promising markers associated with tumor prognosis have also been found. This multi-institutional study aims to validate the diagnostic use of mutational markers in thyroid nodules with indeterminate cytology. The proposed hypothesis is that a broad NGS-based genotyping of thyroid nodules using a large panel of mutational markers applied to thyroid FNA samples can provide an accurate cancer risk stratification in thyroid nodules. The performance of the panel will be tested in a multi-institutional double-blind prospective study of FNA samples from thyroid nodules with indeterminate cytology and available surgical outcome

Thyroid Nodule

University of Pittsburgh256 participantsStarted Jan 2015

Pittsburgh, Pennsylvania, United States

COMPLETEDNA57 miles

Radiofrequency Ablation in Treating Patients With Bone Metastases

NCT00026247

RATIONALE: Radiofrequency ablation may be effective in decreasing pain from bone metastases. PURPOSE: Phase I/II trial to study the effectiveness of radiofrequency ablation in decreasing pain in patients who have bone metastases.

Metastatic CancerPainUnspecified Adult Solid Tumor, Protocol Specific

American College of Radiology Imaging Network66 participantsStarted Nov 2001

Birmingham, Alabama, United States • Worcester, Massachusetts, United States • St Louis, Missouri, United States +5 more locations

Role of NGS-based ThyroSeq Panel in Cancer Diagnosis in Thyroid Nodules

Radiofrequency Ablation in Treating Patients With Bone Metastases

Find Trials by Condition in Pittsburgh

Study Of The Effectiveness & Safety Of Lenalidomide Versus Chlorambucil As First Line Therapy For Elderly Patients With B-Cell CLL (The ORIGIN Trial)

Phase IV Study in Asthma Subjects for Dry Powder Inhaler (DPI) Versus (vs) Metered Dose Inhaler (MDI) Correct Use

S0702: Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metastases

AD-4833/TOMM40_303 Extension Study of the Safety and Efficacy of Pioglitazone to Slow Cognitive Decline in Participants With Mild Cognitive Impairment Due to Alzheimer Disease

ATHENA: Natural History of Disease Study in Alport Syndrome Patients

Two Daily Disposable Contact Lenses in Symptomatic Patients

Evaluation of the Efficacy, Durability, Safety, and Tolerability of RP-G28 in Patients With Lactose Intolerance

Trial Comparing Three Different Devices for Kidney Stone Removal During Percutaneous Surgery

Investigate Safety, Pharmacokinetics and Pharmacodynamics of GSK2118436 & GSK1120212

Continuation Study of the Oral AKT Inhibitor GSK2110183

Correlation of SOZO BIS Measures With CardioMEMS PA Pressure

A Study Evaluating Trastuzumab Emtansine Plus Pertuzumab Compared With Chemotherapy Plus Trastuzumab and Pertuzumab for Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer

Rectal Indomethacin in the Prevention of Post-ERCP Pancreatitis

A Study of Intratumoral CAVATAK™ in Patients With Stage IIIc and Stage IV Malignant Melanoma (VLA-007 CALM )

Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection

A Single-dose Study in Paediatric Patients Aged 2 to Less Than 18 Years With Secondary Hyperparathyroidism (sHPT) Receiving Haemodialysis

Laboratory-Treated Lymphocyte Infusion After Haploidentical Donor Stem Cell Transplant

Efficacy and Safety Study of Deferiprone in Patients With Pantothenate Kinase-associated Neurodegeneration (PKAN)