Clinical Trials in Pittsburgh

Showing 13081-13100 of 21,047 trials

Safety, Tolerability, and Efficacy of MTP-131 for the Treatment of Mitochondrial Myopathy

NCT02367014

Phase 1/2, multi-center, randomized, double-blind, multiple ascending dose, placebo-controlled study that enrolled 36 subjects with mitochondrial myopathy associated with genetically confirmed mitochondrial disease to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of MTP-131 in this patient population.

Mitochondrial Myopathy

Stealth BioTherapeutics Inc.36 participantsStarted Feb 2015

San Diego, California, United States • Boston, Massachusetts, United States • Akron, Ohio, United States +1 more locations

COMPLETEDNA< 1 mile

The SleepTrackTXT2 Randomized Trial With Air-medical Personnel

NCT02783027

The overarching goal of this proposal is to address the MedEvac foundation priority of educational techniques and technologies and improve Helicopter Emergency Medical Services (HEMS) safety by determining if overall sleep quality and intra-shift fatigue of HEMS clinicians can be improved with real-time assessment and intervention. Aim 1: To determine the short-term impact of an enhanced SleepTrackTXT intervention on HEMS clinician fatigue reported in real-time during and at the end of shift work. Aim 2: To determine the long-term impact of the SleepTrackTXT intervention on sleep quality and sleep health indicators including hours of sleep and recovery between shift work.

Poor Quality SleepFatigue

University of Pittsburgh83 participantsStarted Jun 2016

Pittsburgh, Pennsylvania, United States

Safety, Tolerability, and Efficacy of MTP-131 for the Treatment of Mitochondrial Myopathy

The SleepTrackTXT2 Randomized Trial With Air-medical Personnel

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An Open-Label Extension of BPS-MR-PAH-201 in Pulmonary Arterial Hypertension (PAH) Patients

EverFlex Post Approval Study

12-Week Study of Plecanatide for CIC (The CIC3 Study)

Safety and Efficacy of Vilazodone in Adolescent Patients With Major Depressive Disorder

Fulvestrant With or Without Lapatinib in Treating Postmenopausal Women With Stage III or Stage IV Breast Cancer That is Hormone Receptor-Positive

Cobiprostone Prevention of NSAID-induced Gastroduodenal Injury

A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-02)

A Study of Atezolizumab (an Engineered Anti-Programmed Death-Ligand 1 [PD-L1] Antibody) as Monotherapy or in Combination With Bevacizumab (Avastin®) Compared to Sunitinib (Sutent®) in Participants With Untreated Advanced Renal Cell Carcinoma

Pediatric Open-Label Extension Study

Evaluation of the Efficacy and Safety of Lubiprostone in Adults With Mixed or Unsubtyped Irritable Bowel Syndrome

Study to Evaluate Equivalence of Estradiol Vaginal Cream 0.01% to Estrace® Cream 0.01% in Atrophic Vaginitis

Comparison of Inhaled Nitric Oxide and Oxygen in Participants Reactivity During Acute Pulmonary Vasodilator Testing

Longitudinal Evaluation of [18F]GTP1 as a PET Radioligand for Imaging Tau in the Brain of Participants With Alzheimer's Disease Compared to Healthy Participants

An Extension Study of ABT-199 in Subjects With Advanced Non-Hodgkin's Lymphoma

Trial of Three Stem Cell Mobilization Regimens for Multiple Myeloma

Evaluate the Clinical Effectiveness of RegenKit Platelet-rich Plasma (PRP) in Androgenetic Alopecia Treatment

A Depot Formulation of Sunitinib Malate (GB-102) in Subjects With Neovascular (Wet) Age-related Macular Degeneration

A Study to Describe Patterns of Care and Outcomes of Men Who Are at High Risk After Experiencing Biochemical Failure Following Definitive Prostate Cancer Therapy, Men With Castration-resistant Prostate Cancer and Men With Metastatic Prostate Cancer