Clinical Trials in Pittsburgh

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Melanoma Molecular Profiling Analysis

NCT00889980

There is a significant need to develop new and more effective ways to treat melanoma that will decrease patient morbidity and mortality. This protocol intends to collect and process a portion (\< 20% of any node) of lymph nodes from melanoma patients undergoing routine surgical SLN resection: the SLN(s) and 1 adjacent non-SLN(s) are planned for study. In addition, blood will be drawn at the pre study visit (serum and peripheral blood mononuclear cells) and appropriate lineage control tissue will be collected. Material only from already-indicated and planned procedures as part of standard medical care will be used. The main goal of this study will be to properly collect and process material to be analyzed and explore the molecular features melanoma biological samples.

Melanoma

University of Pittsburgh237 participantsStarted May 2008

Pittsburgh, Pennsylvania, United States

COMPLETEDPhase 3< 1 mile

Radiation Therapy (RT) and Temozolomide (TMZ) in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

NCT00304031

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may kill more tumor cells. It is not yet known which schedule of temozolomide when given together with radiation therapy is more effective in treating glioblastoma or gliosarcoma. PURPOSE: This randomized phase III trial is studying two different schedules of temozolomide to compare how well they work when given together with radiation therapy in treating patients with newly diagnosed glioblastoma or gliosarcoma.

Brain and Central Nervous System Tumors

Radiation Therapy Oncology Group1,173 participantsStarted Jan 2006

Fairbanks, Alaska, United States • Phoenix, Arizona, United States • Scottsdale, Arizona, United States +348 more locations

Melanoma Molecular Profiling Analysis

Radiation Therapy (RT) and Temozolomide (TMZ) in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Find Trials by Condition in Pittsburgh

Clinical Evaluation of the Sentosa SA HSV1/2 Qualitative PCR Test

Randomized Study of Organ Care System Cardiac for Preservation of Donated Hearts for Eventual Transplantation

A Study of ATI-50002 Topical Solution for the Treatment of Alopecia Areata

GSK2982772 Study in Subjects With Ulcerative Colitis

My Life, My Healthcare

Efficacy and Safety of NYX-2925 in Subjects With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy

Phase I Study of LDK378 in Pediatric, Malignancies With a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK)

Pharmacokinetics of Anti-epileptic Drugs in Obese Children

LEVANT 2 Safety Registry

Phase 1/2a Dose-Escalation Study of CRLX301 in Patients With Advanced Solid Tumors

Oral Omadacycline vs. Oral Nitrofurantoin for the Treatment of Cystitis

VAL-1221 Delivered Intravenously in Ambulatory and Ventilator-free Participants With Late-Onset Pompe Disease

Chemotherapy Before & After Surgery in Patients With Resectable Gallbladder Cancer

Geriatric Fracture Centers - Evaluation of a Geriatric Co-management Program

A Trial To Evaluate A Multivalent Pneumococcal Conjugate Vaccine In Healthy Adults 50-85 Years Of Age

Dose Timing of D-Cycloserine to Augment CBT for Social Anxiety Disorder

Study of the Safety, Tolerability and Pharmacokinetics of TIMP-GLIA in Subjects With Celiac Disease

An International Survey of the Occurrence of Cardiovascular Disease Among Patients With Type 2 Diabetes