Clinical Trials in Pittsburgh

Showing 8901-8920 of 21,047 trials

Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study

NCT03911492

This multicenter study will enroll 100 patients with acute traumatic cervical and thoracic SCI who have a lumbar intrathecal catheter inserted within 24 hours of their injury. The lumbar intrathecal catheter will be inserted pre-operatively for the measurement of ITP and the collection of cerebrospinal fluid (CSF) samples. SCPP will be calculated as the difference between MAP and the ITP. There are two important distinct yet related objectives in this prospective interventional study. 1. Determine the effect of SCPP maintenance ≥ 65 mmHg in acute SCI on neurologic recovery as measured by ASIA Impairment Scale (AIS) grade conversion and motor score improvement. 2. Collect CSF and blood samples for the measurement of neurochemical biomarkers and storage for future biomarker discovery and validation studies.

Acute Spinal Cord InjuryAcute Spinal ParalysisSpinal Cord Injuries+1 more

University of British Columbia100 participantsStarted Aug 2019

San Francisco, California, United States • Omaha, Nebraska, United States • Albuquerque, New Mexico, United States +5 more locations

COMPLETEDPhase 2< 1 mile

Esophagectomy in Treating Patients With High-Grade Dysplasia of the Esophagus or Stage I, Stage II, or Stage III Esophageal Cancer

NCT00063986

RATIONALE: Laparoscopic-assisted surgery and video-assisted thoracoscopy are less invasive types of surgery for esophageal cancer that may have fewer side effects and improve recovery. PURPOSE: This phase II trial is studying how well laparoscopic-assisted surgery and video-assisted thoracoscopy work in treating patients who are undergoing esophagectomy for high-grade dysplasia of the esophagus or stage I, stage II, or stage III esophageal cancer.

Esophageal Cancer

Eastern Cooperative Oncology Group110 participantsStarted Jun 2004

Orange, California, United States • Savannah, Georgia, United States • Chicago, Illinois, United States +38 more locations

Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study

Esophagectomy in Treating Patients With High-Grade Dysplasia of the Esophagus or Stage I, Stage II, or Stage III Esophageal Cancer

Find Trials by Condition in Pittsburgh

A Phase 2b Study to Evaluate RIST4721 in Palmoplantar Pustulosis (PPP)

PEG-Interferon Alfa-2b in Treating Patients With Stage IV Melanoma

Sorafenib in Treating Patients With Refractory Non-Small Cell Lung Cancer

Study to Evaluate the Safety and Efficacy of Oral CR845 (Difelikefalin) in Patients With Primary Biliary Cholangitis (PBC) and Moderate-to-Severe Pruritus

Bendamustine Hydrochloride and Rituximab With or Without Bortezomib Followed by Rituximab With or Without Lenalidomide in Treating Patients With High-Risk Stage II, Stage III, or Stage IV Follicular Lymphoma

Rituximab and Combination Chemotherapy in Treating Patients With Primary Central Nervous System Lymphoma

PNT2258 for Treatment of Patients With r/r DLBCL (Wolverine)

Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer

Study to Determine the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Eosinophilic Esophagitis (EoE)

Erythropoietin (EPO)+/- Filgrastim (G-CSF) vs. Supportive Therapy Alone for Patients With Myelodysplastic Syndromes

Dissemination and Implementation of Stroke Prevention Looking at the Care Environment

Cyclosporine in Treating Patients With Recurrent or Refractory Angioimmunoblastic T-Cell Lymphoma

BioWave High-frequency Neurostimulation Versus TENS for the Treatment of Chronic Low Back Pain

Safety, Tolerance, PK, and Anti-tumour Activity of AZD1775 Monotherapy in Patients With Advanced Solid Tumours

A Phase 3 Lot to Lot Consistency Study of Live Oral Cholera Vaccine, PXVX0200 in Healthy Adults

PNT2258 for Treatment of Patients With Richter's Transformation (Brighton)

Study of Verinurad in Heart Failure With Preserved Ejection Fraction

MP1032 Treatment in Patients With Moderate to Severe COVID-19