Clinical Trials in Pittsburgh

Showing 7961-7980 of 21,047 trials

Oral AHR Antagonist in Combination With Nivolumab in Patients With PD-1 Resistant Metastatic or Recurrent Head and Neck Cancer

NCT05472506

This is a phase 1b study in adult patients diagnosed with resistant or recurrent head and neck squamous cell carcinoma (HNSCC) designed to assess the safety and tolerability of IK-175 in combination with nivolumab. Disease response, pharmacokinetics (PK), pharmacodynamics, and response biomarkers will also be assessed.

Head and Neck Squamous Cell CarcinomaHead and Neck CancerHead Cancer+3 more

Ikena OncologyStarted Mar 2023

Chicago, Illinois, United States • St Louis, Missouri, United States • Pittsburgh, Pennsylvania, United States +1 more locations

COMPLETEDNA< 1 mile

Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain

NCT05022121

Guidelines advocate several complementary modalities as alternatives to drugs and other invasive treatments for chronic low back pain (LBP) conditions. However, there is little high-quality research investigating treatments for back-related leg pain, one of the more severe and disabling presentations of LBP. The investigators are conducting a pilot study to assess the feasibility of a future phase II multi-site randomized clinical trial (RCT). The future trial will assess the comparative effectiveness of a novel supported biopsychosocial self-management (SBSM) intervention versus Medical Care (MC).

Low Back PainSciaticaBack Related Leg Pain+2 more

University of Minnesota42 participantsStarted Jan 2022

Minneapolis, Minnesota, United States • Pittsburgh, Pennsylvania, United States

Oral AHR Antagonist in Combination With Nivolumab in Patients With PD-1 Resistant Metastatic or Recurrent Head and Neck Cancer

Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain

Find Trials by Condition in Pittsburgh

Avelumab in Participants With Merkel Cell Carcinoma (JAVELIN Merkel 200)

A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men

Robotic-assisted and Laparoscopic Right Colectomy Study - Intracorporeal vs. Extracorporeal Anastomoses

Oral Infigratinib for the Adjuvant Treatment of Subjects With Invasive Urothelial Carcinoma With Susceptible FGFR3 Genetic Alterations

Osimertinib With Stereotactic Radiosurgery (SRS) in Brain Metastases From EGFR Positive NSCLC

Evaluation of the PrevisEA Device for Predicting Gastrointestinal Impairment

Long-term Access Program (LAP) of Mepolizumab for Subjects Who Participated in Study MEA115921

Study to Evaluate Amifampridine Phosphate in Patients With MuSK-MG

A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors

A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis

Platform Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With aOX40 (GSK3174998) in Participants With RRMM

Study to Assess the Efficacy and Safety of Emapalumab in Primary Haemophagocytic Lymphohistiocytosis

Multi-center Phase I/IIa Trial of an Autologous Tumor Lysate (TL) + Yeast Cell Wall Particles (YCWP) + Dendritic Cells (DC) Vaccine in Addition to Standard of Care Checkpoint Inhibitor of Choice in Metastatic Melanoma Patients With Measurable Disease.

Prospective SPINE Registry

A Study to Evaluate Safety, Efficacy, and Pharmacokinetics in Participants With Advanced Solid Tumors

A Study of Purified Inactivated Zika Virus Vaccine (PIZV) in Healthy Adults

A Study of hSTC810 With Advanced/Metastatic Solid Tumors (STCUBE-001)

Losmapimod Safety and Efficacy in COVID-19