Clinical Trials in Pittsburgh

Showing 6661-6680 of 21,047 trials

Effects of Amygdala Neurofeedback on Depressive Symptoms

NCT02709161

The purpose of this study is to determine the clinical efficacy of augmenting cognitive-behavioral therapy with real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) training to increase the amygdala's response to positive autobiographical memories.

Major Depressive Disorder

Kymberly Young36 participantsStarted Oct 2016

Pittsburgh, Pennsylvania, United States

Active Not RecruitingPhase 1/277 miles

BXQ-350 in Newly Diagnosed Metastatic Colorectal Carcinoma

NCT05322590

The study will assess the safety and efficacy of BXQ-350 plus modified FOLFOX7 (mFOLFOX7) and bevacizumab in participants who have newly diagnosed metastatic adenocarcinoma of the colon/rectum. The study will also evaluate if the administration of BXQ-350 with mFOLFOX7 and bevacizumab may diminish oxaliplatin induced sensory neurotoxicity, enabling participants to receive the total and planned doses of mFOLFOX7. All participants will receive BXQ-350 by intravenous (IV) infusion along with standard of care doses of mFOLFOX and bevacizumab. The study is divided into two stages: Stage 1 will be open label and will enroll participants at increasing dose levels of BXQ-350 in order to determine the Stage 2 dose. Stage 2 will be blinded; participants will receive BXQ-350 at the established Stage 1 dose or placebo.

Metastatic Colorectal CarcinomaNeuropathy

Bexion Pharmaceuticals, Inc.195 participantsStarted Jan 2023

Birmingham, Alabama, United States • Orange, California, United States • San Francisco, California, United States +9 more locations

Effects of Amygdala Neurofeedback on Depressive Symptoms

BXQ-350 in Newly Diagnosed Metastatic Colorectal Carcinoma

Find Trials by Condition in Pittsburgh

VTX958 Versus Placebo for the Treatment of Active Psoriatic Arthritis (Tranquility-PsA)

Extension Study of Pimavanserin in Adult Subjects With Neuropsychiatric Symptoms Related to Neurodegenerative Disease

A Study of Rebastinib (DCC-2036) in Combination With Carboplatin in Patients With Advanced or Metastatic Solid Tumors

A Phase 2 Study of MP-376 to Prevent Acute Exacerbations in Chronic Obstructive Pulmonary Disease (COPD) Patients

A Study Evaluating Potential Disease-Mediated Drug-Drug Interaction in Adult Participants With Active Eosinophilic Esophagitis Receiving Cendakimab

Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA Vaccine Candidate Variations in Healthy Adults

Chimney EndoVascular Aneurysm Sealing Of New Expanded Indication

Investigation of Safety, Tolerability and Maximum Tolerated Dose (MTD) of BI 2536 in Patients With Recurrent Advanced Aggressive Non-Hodgkin's Lymphoma (NHL)

A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty

A Study to Evaluate the Safety and Efficacy of AZD5718 in Participants With Proteinuric Chronic Kidney Disease

Dose Escalation and Expansion Study of GSK3359609 in Participants With Selected Advanced Solid Tumors (INDUCE-1)

Oral AMXT 1501 Dicaprate in Combination With IV DFMO

ONC201 in Recurrent or Metastatic Type II Endometrial Cancer Endometrial Cancer

Durvalumab Followed by Chemoradiation and Consolidation Durvalumab for Stage III Non-small Cell Lung Cancer

Study of SIRPant-M in Participants With Relapsed or Refractory Non-Hodgkin's Lymphoma

Study to Assess Safety, Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Participants With Locally Advanced or Metastatic Solid Tumors

Oral ONC201 in Adult Recurrent Glioblastoma

Global Fenestrated Anaconda Clinical STudy