Clinical Trials in Pittsburgh

Showing 6401-6420 of 21,047 trials

Selumetinib and Cyclosporine in Treating Patients With Advanced Solid Tumors or Advanced or Metastatic Colorectal Cancer

NCT02188264

This phase I/Ib trial studies the side effects and best dose of selumetinib when given together with cyclosporine in treating patients with solid tumors or colorectal cancer that have spread to other places in the body and cannot be cured or controlled with treatment. Selumetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Biological therapies, such as cyclosporine, use substances made from living organisms that may stimulate or suppress the immune system in different ways and stop tumor cells from growing. Giving selumetinib and cyclosporine may be a better treatment for solid tumors or colorectal cancer.

Recurrent Colorectal CarcinomaSolid NeoplasmStage IIIA Colorectal Cancer AJCC v7+4 more

National Cancer Institute (NCI)40 participantsStarted Aug 2014

Sacramento, California, United States • Aurora, Colorado, United States • Creve Coeur, Missouri, United States +7 more locations

RECRUITINGNA53 miles

Rising Tide - Amniotic Tissue(s) Treatments for Chronic Diabetic Foot Ulcers

NCT06681428

The purpose of this clinical investigation is to evaluate the safety and efficacy of Amnion/Chorion/Amnion allograft , Amnion/Chorion allograft, and/or Amnion/Amnion allograft, plus Standard of Care (SOC) each versus SOC alone in the treatment of chronic non-healing diabetic foot ulcers (DFU) after 12 weeks of treatment.

Diabetic Foot Ulcer (DFU)Chronic Foot Ulcers

Tides Medical240 participantsStarted Nov 2024

Fresno, California, United States • Los Angeles, California, United States • Los Angeles, California, United States +6 more locations

Selumetinib and Cyclosporine in Treating Patients With Advanced Solid Tumors or Advanced or Metastatic Colorectal Cancer

Rising Tide - Amniotic Tissue(s) Treatments for Chronic Diabetic Foot Ulcers

Find Trials by Condition in Pittsburgh

A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Upadacitinib in Pediatric Participants With Severe Atopic Dermatitis

A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies

Non-comparative Study of IFX-1 Alone or IFX-1+Pembrolizumab in Patients With Locally Advanced or Metastatic cSCC.

(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations

A Study of SGN-ALPV in Advanced Solid Tumors

Futibatinib Versus Gemcitabine-Cisplatin Chemotherapy as First-Line Treatment of Patients With Advanced Cholangiocarcinoma Harboring FGFR2 Gene Rearrangements

A Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of PGDM1400LS Alone and in Combination With VRC07-523LS and PGT121.414.LS in Healthy, HIV-uninfected Adult Participants

Surveillance and Alert-based Multiparameter Monitoring to Reduce Worsening Heart Failure Events

Evaluation of SAR408701 in Patients With Advanced Solid Tumors

NB-001 in Children and Adolescents With 22q11 Deletion Syndrome

A Food Additive Removal Diet for Pediatric Eosinophilic Esophagitis

A Study of the Safety and Tolerability in Participants With PIK3CA-related Overgrowth Spectrum or Proteus Syndrome Who Are Being Treated With Miransertib (MK-7075) in Other Studies (MK-7075-006)

A Study of Participants with Β-Thalassemia Treated with Betibeglogene Autotemcel

Study of ExoFlo for the Treatment of Medically Refractory Crohn's Disease

Administration of Hydroxychloroquine (Plaquenil) to African Americans and Hispanics for the Treatment of Mild to Severe Ulcerative Colitis

A Trial of a Novel XPO1 Inhibitor in Participants With Advanced Solid Tumors

A Study of Imvotamab in Severe Systemic Lupus Erythematosus

Foot and Ankle Post-operative Oedema Management Using Geko™