Clinical Trials in Pittsburgh

Showing 6261-6280 of 21,047 trials

A Phase II Study of Pre-Op SRS Followed by Surgical Resection for Brain Metastases

NCT05341739

This is a research study to determine if performing stereotactic radiosurgery (SRS) prior to surgical resection of the brain metastasis (tumor) will improve local control, in other words, increase the possibility of total removal of the primary tumor without local recurrence on longterm follow up. This research study will also determine if pre-operative SRS will lower the risk of radionecrosis that is the breakdown of body tissue at the original tumor site, and the development of leptomeningeal disease.

Brain Metastases, Adult

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)20 participantsStarted Dec 2021

Pittsburgh, Pennsylvania, United States

Active Not RecruitingPhase 2< 1 mile

Phase 2a to Evaluate PL-8177 in Subjects with Active Ulcerative Colitis (UC)

NCT05466890

The purpose of this study is to compare PL8177 (a melanocortin receptor agonist) to placebo (in a 3:1 ratio-meaning that for every 3 people that get the active drug, one will receive placebo). The study treatment will be for 8 weeks. The study will measure safety and the body's ability to handle PL8177 and look at the improvement and healing of the intestine after 8 weeks of treatment. The study will include adult males and nonpregnant, nonlactating females with acute Ulcerative Colitis (UC).

Ulcerative ColitisUlcerative Colitis AcuteUlcerative+1 more

Palatin Technologies, Inc16 participantsStarted Sep 2022

Tucson, Arizona, United States • Lancaster, California, United States • Tarzana, California, United States +11 more locations

A Phase II Study of Pre-Op SRS Followed by Surgical Resection for Brain Metastases

Phase 2a to Evaluate PL-8177 in Subjects with Active Ulcerative Colitis (UC)

Find Trials by Condition in Pittsburgh

Study to Assess the Safety and Immunogenicity of GSK Meningococcal Group B Vaccine When Administered Concomitantly With GSK Meningococcal MenACWY Conjugate Vaccine in Healthy Subjects of 16-18 Years of Age

A Study to Evaluate the Anti-inflammatory Effects of Letermovir (Prevymis) in Adults With Human Immunodeficiency Virus (HIV)-1 and Asymptomatic Cytomegalovirus (CMV) Who Are on Suppressive Antiretroviral Therapy, Plus Its Effect on Chronic Inflammation, HIV Persistence and Other Clinical Outcomes.

AZithromycin Therapy in Preschoolers With a Severe Wheezing Episode Diagnosed at the Emergency Department

Cisplatin and Gemcitabine Hydrochloride With or Without Berzosertib in Treating Patients With Metastatic Urothelial Cancer

Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation (PARAGLIDE-HF)

Safety and Activity Study of an Oral Medication to Treat Moderate to Severe Crohn's Disease

Study of EYP-1901 in Patients With Diabetic Macular Edema (DME)

Screening Protocol for Tumor Antigen Expression Profiling and HLA Typing for Eligibility Determination

Observational Study of Persistence on Bafiertam Treatment in Routine Clinical Practice

Study of Lanreotide Autogel in Non-functioning Entero-pancreatic Endocrine Tumours

Maintenance NeuroStar Transcranial Magnetic Stimulation (TMS) in Patients With Major Depressive Disorder

ViBone in Cervical and Lumbar Spine Fusion

Phase 2 Trial to Evaluate Belzupacap Sarotalocan (AU-011) Via Suprachoroidal Administration in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma

A Socio-ecological Approach for Improving Self-management in Adolescents With SCD

A Study of JNJ-80038114 in Participants With Advanced Stage Prostate Cancer

T-DM1+Pertuzumab in Pre-OP Early-Stage HER2+ BRCA

Rapid On Site Evaluation of Pleural Touch Preparations in Diagnosing Malignant Pleural Effusion in Patients Undergoing Pleuroscopy

Information Visualizations to Enhance HIV-related Communication