Clinical Trials in Pittsburgh

Showing 5321-5340 of 21,047 trials

STRIDE Study - A Study in Subjects With LOPD Who Are Currently Being Treated With ERT

NCT03347253

The purpose of the study is to evaluate changes in key clinical outcome measures (eg, motor, respiratory, fatigue) in adult subjects with late-onset Pompe disease (LOPD) subjects receiving standard-of-care enzyme replacement therapy (ERT). Additionally, information gained may be used in the design and conduct of future studies in LOPD subjects.

Late-onset Pompe Disease

Amicus Therapeutics12 participantsStarted Dec 2017

Irvine, California, United States • Gainesville, Florida, United States • Decatur, Georgia, United States +18 more locations

Active Not RecruitingPhase 1< 1 mile

Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers

NCT04460937

This phase I trial investigates the side effects and best dose of adavosertib and how well it works when given in combination with radiation therapy in treating patients with esophageal or gastroesophageal junction cancer for which no treatment is currently available (incurable). Adavosertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving adavosertib together with radiation therapy kill more tumor cells than radiation therapy alone in treating patients with esophageal and gastroesophageal junction cancer.

Clinical Stage III Esophageal Adenocarcinoma AJCC v8Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8+56 more

National Cancer Institute (NCI)4 participantsStarted Apr 2021

Duarte, California, United States • Chicago, Illinois, United States • Lexington, Kentucky, United States +4 more locations

STRIDE Study - A Study in Subjects With LOPD Who Are Currently Being Treated With ERT

Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers

Find Trials by Condition in Pittsburgh

Patient Perceived Empathy of an AI Chatbot for Atrial Fibrillation Education

Efficacy of Oral Azacitidine Plus Best Supportive Care as Maintenance Therapy in Subjects With Acute Myeloid Leukemia (AML) in Complete Remission

Community Resiliency Collective Efficacy Intervention

Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

Clinical Study of CMP-001 in Combination With Pembrolizumab or as a Monotherapy

Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure

Circumferential Vertebral Reconstruction of Osteoporotic Compression Fractures Using a Novel Bipedicular Peek Implant

A Ph2b to Evaluate Clinical Efficacy and Safety of Tildacerfont in Adult CAH

Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease

A Study to Compare the Efficacy and Safety of SCENESSE and Narrow-Band Ultraviolet (NB-UVB) Light Versus NB-UVB Light Alone in Patients With Vitiligo

CHIO3 Trial: CHemotherapy Combined With Immune Checkpoint Inhibitor for Operable Stage IIIA/B Non-Small Cell Lung Cancer

Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2i) in Subjects With Hypertension and Chronic Kidney Disease (CKD) With Albuminuria

A Study of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib Given in Combination With Bendamustine and Rituximab in Patients With Newly Diagnosed Mantle Cell Lymphoma

Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome

A Study of GlcNAc on Tear Production in NGLY1-CDDG

GWICTIC: NAC Mechanistic Study in Gulf War Veterans

Rare Kidney Stone Consortium Patient Registry

Stage II/III Colorectal Cancer Recurrence