Clinical Trials in Pittsburgh

Showing 4521-4540 of 21,047 trials

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

NCT02070744

The objective of this study was to evaluate the safety and efficacy of VX-661in combination with ivacaftor in participants with cystic fibrosis (CF) who are homozygous for F508del cystic fibrosis transmembrane conductance regulator (CFTR) mutation

Cystic Fibrosis

Vertex Pharmaceuticals Incorporated40 participantsStarted Mar 2014

Birmingham, Alabama, United States • Palo Alto, California, United States • Stanford, California, United States +20 more locations

COMPLETEDPhase 2< 1 mile

Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis

NCT04340362

This study will evaluate the efficacy, safety and pharmacokinetics (PK) of VX-147 in participants with apolipoprotein L1 (APOL1)-mediated focal segmental glomerulosclerosis (FSGS).

Glomerulosclerosis, Focal Segmental

Vertex Pharmaceuticals Incorporated16 participantsStarted Jun 2020

Birmingham, Alabama, United States • San Diego, California, United States • Washington D.C., District of Columbia, United States +41 more locations

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis

Find Trials by Condition in Pittsburgh

Study on Two Adjuvanted Dose Levels of Panblok H7+MF59 Compared for Immunogenicity and Safety With an Unadjuvanted Dose of Panblok H7 in Participants 18 Years of Age and Older

Mobile Strategy to Reduce the Risk of Recurrent Preterm Birth

A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

A Study to Evaluate the Efficacy and Safety of BLI5100 in Patients With Erosive Esophagitis

A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation

A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations

Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 in Participants With Congenital Adrenal Hyperplasia (TouCAHn)

Phase 2 Safety and Efficacy Evaluation of AL8326 in ≥2nd Line SCLC

Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors

A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium

A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2

A Study Testing the Use of a Perivascular Sirolimus Formulation (Sirogen) in ESRD Patients Undergoing AV Fistula Surgery

Single-Sided Deafness and Asymmetric Hearing Loss

Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery

Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

Metabolic Mechanisms Induced by Enteral DHA and ARA Supplementation in Preterm Infants

Computerized Registry of Patients With Venous Thromboembolism (RIETE)

Phase1/2a Study for IPG7236 in Patients With Advanced Solid Tumors