Clinical Trials in Pittsburgh

Showing 2741-2760 of 18,076 trials

REACTION (Radiation Enhanced Assessment of Combination Therapies in Immuno-ONcology) - Nivolumab or Nivolumab in Combination With Other Immuno-oncology (IO) Agents After Targeted Systemic Radiation in Patients With Advanced Esophagogastric Cancer

NCT03610711

This is a Phase 1B study assessing the safety of immune checkpoint inhibition after SBRT in patients with recurrent or metastatic gastroesophageal cancer (limited metastatic disease).

Gastroesophageal CancerImmune Checkpoint Inhibition

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins21 participantsStarted Mar 2019

Baltimore, Maryland, United States • Pittsburgh, Pennsylvania, United States • Dallas, Texas, United States

COMPLETED< 1 mile

Spreading Depolarizations in Traumatic Brain Injury

NCT03379220

This research aims to extend the application of spreading depolarization monitoring to non-surgical TBI patients, using intraparenchymal electrode arrays and scalp electroencephalography to detect depolarizations and develop less invasive monitoring methods.

Traumatic Brain Injury

University of Cincinnati147 participantsStarted Mar 2017

San Francisco, California, United States • Miami, Florida, United States • Boston, Massachusetts, United States +4 more locations

RECRUITINGNA< 1 mile

ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

NCT05172973

The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4 Transcatheter Heart Valve (THV) in subjects who are at high or greater risk with a failing aortic bioprosthetic valve.

Aortic Valve InsufficiencyAortic Valve Stenosis

Edwards Lifesciences200 participantsStarted Nov 2023

Newport Beach, California, United States • San Francisco, California, United States • San Francisco, California, United States +32 more locations

REACTION (Radiation Enhanced Assessment of Combination Therapies in Immuno-ONcology) - Nivolumab or Nivolumab in Combination With Other Immuno-oncology (IO) Agents After Targeted Systemic Radiation in Patients With Advanced Esophagogastric Cancer

Spreading Depolarizations in Traumatic Brain Injury

ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

Find Trials by Condition in Pittsburgh

A Trial to Assess the Long-term Safety of Octreotide Subcutaneous Depot in Patients With Acromegaly

Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC

Pembrolizumab With Carboplatin Compared to Carboplatin Alone in Breast Cancer Patients With Chest Wall Disease

Testing Interruption of Hormonal Medications in Patients Responding Exceptionally to Therapy for Metastatic Prostate Cancer, (A-DREAM)

Phase 2b/3 Study to Assess ABP-671 a Novel URAT1 Inhibitor in Participants With Gout

NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

A Study to Compare How Well Gadoquatrane Works and Its Safety With an Already Available Contrast Agent for MRI in People With Any Known or Suspected Problems of the Body (Except Brain or Spinal Cord-related Problems)

ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty

Diagnosing Clinically Significant Prostate Cancer In African American and White Men With Elevated PSA

A Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis

A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years

A Study of AMG 355 Alone and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

KYSA-8: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Treatment Refractory Stiff Person Syndrome

Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc

NuVasive® ACP System Study

Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV)

iAmHealthy Clinical Practice Guideline (CPG)