Clinical Trials in Pittsburgh

Showing 20901-20920 of 21,047 trials

Trial of rPA-102 Vaccine in Healthy Adult Volunteers

NCT00100724

The purpose of this study is to assess the safety and immunogenicity of rPA102 vaccine given intramuscularly at 0 and 4 weeks over 2 dose ranges and 4 adjuvant levels.

Anthrax

VaxGen480 participantsStarted Apr 2004

Torrance, California, United States • Atlanta, Georgia, United States • Lexington, Kentucky, United States +9 more locations

COMPLETEDPhase 3< 1 mile

Safety and Efficacy of Galantamine in Patients With Dementia With Lewy Bodies

NCT00230997

TRIAL SUMMARY: This is an open-label, 24-week, investigator initiated study to evaluate the safety and efficacy of galantamine (16 8 to 24 mg/day; flexible dosing) in the treatment of Dementia with Lewy bodies. The primary efficacy variables will be the NPI -12, the COGDRAS tests of attention and visuospatial orientation, and the ADCS-CGIC. The secondary efficacy variables will be the MMSE, ADCS-ADL-Inventory, ADAS-Cog, PSQI, and the use of concomitant rescue antipsychotic medication. PET scanning will be obtained on 10 patients at one site. An interim analysis will also be performed. Safety outcome measures will be adverse event reports, vital signs, physical examinations, ECG, laboratory parameters and the UPDRS (motor subscale).

Lewy Body Disease

Neurological Research Center50 participantsStarted Dec 2002

Indianapolis, Indiana, United States • Buffalo, New York, United States • Pittsburgh, Pennsylvania, United States +2 more locations

Trial of rPA-102 Vaccine in Healthy Adult Volunteers

Safety and Efficacy of Galantamine in Patients With Dementia With Lewy Bodies

Find Trials by Condition in Pittsburgh

Depression: The Search for Treatment-Relevant Phenotypes-Pilot Study

Dose-Response of Exercise on Long-Term Weight Loss

Effect of Exercise on Prevention of Weight Gain

Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study

Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia.

Safety and Efficacy of Pletal (Cilostazol) for the Treatment of Juvenile Primary and Secondary Raynaud's Phenomenon

A Phase I/II Study of Lenalidomide in Combination With Gemcitabine in Patients With Untreated Advanced Carcinoma of the Pancreas

The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study

Intravitreous Pegaptanib Sodium Injection in Patients With Exudative Age-Related Macular Degeneration (AMD)

Safety and Efficacy of Pletal(Cilostazol) for the Treatment of Juvenile Primary and Secondary Raynaud's Phenomenon

A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis

Xcellerated T CellsTM in Patients With Multiple Myeloma

TBTC Study 23A: Pharmacokinetics of Intermittent Isoniazid and Rifabutin in HIV-TB

TBTC Study 23B:Intensive PK of the Nelfinavir Rifabutin Interaction in Patients With HIV-TB

Treatment of Hallucinosis/Psychosis in Parkinson's Disease by an Investigational Drug

Study to Demonstrate That Muscle Pattern Recognition (MPR) is an Effective Evaluation Tool for Musculoskeletal Neck or Back Pain

Phase I Open-Label, Dose Escalation Study To Determine The Maximum Tolerated Dose And To Evaluate The Safety Profile Of Lenalidomide (Revlimid®, CC-5013) With Pemetrexed In Subjects With Advanced Non-Small Cell Lung Cancer

Study of NS-9 in Patients With Liver Metastases