Clinical Trials in Pittsburgh

Showing 2021-2040 of 18,076 trials

Anticholinergic Deprescription in Schizophrenia

NCT06562608

In this study, the investigators will examine whether a deprescription of unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can augment quality of life, functioning, and neurocognition in individuals who with schizophrenia. Individuals identified by clinical services who have unneeded prescriptions benztropine or trihexyphenidyl will be eligible for deprescription and study entry. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will will be randomized to either staying on their anticholinergic drugs or undergoing deprescription per routine clinical care, and will undergo follow-up evaluations across 6 months. The investigators predict that reducing and deprescribing these drug, if clinically determined to be unnecessary will will enhance functioning, neurocognition

SchizophreniaSchizoaffective Disorder

Deepak K. Sarpal, M.D.105 participantsStarted Feb 2025

Pittsburgh, Pennsylvania, United States

RECRUITINGPhase 2< 1 mile

Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer

NCT04080804

The aim of this study is to potentiate adaptive immunity to enhance the anti-tumor activity of anti-PD1 antibody by the addition of anti-CTLA4 antibody or anti-LAG3 antibody (relatlimab) given in subjects with resectable locally advanced HNSCC prior to surgical resection.

Head and Neck Squamous Cell Carcinoma (HNSCC)

Dan Zandberg80 participantsStarted Dec 2019

Pittsburgh, Pennsylvania, United States

Anticholinergic Deprescription in Schizophrenia

Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer

Find Trials by Condition in Pittsburgh

Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis

School Partnered Collaborative Care (SPACE) Intervention for Children With Type 1 Diabetes

Longitudinal Study of Neurodegenerative Disorders

Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)

LINX Reflux Management System or Fundoplication Clinical Study in Patients With Hiatal Hernia >3 cm

Enhancing Prefrontal Oscillations and Working Memory in Early-course Schizophrenia

FX Shoulder Prospective Clinical Study

A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations

A Study Evaluating the Efficacy and Safety of Vixarelimab in Participants With Idiopathic Pulmonary Fibrosis and in Participants With Systemic Sclerosis-Associated Interstitial Lung Disease

A Trial Investigating the Safety, Tolerability and Efficacy of TransCon PTH Administered Daily in Adults With Hypoparathyroidism

An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH

Avapritinib Rollover Study

ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)

LURN: Urinary Urgency Phenotyping Protocol

Expanded Access Protocol (EAP) for Nonconforming (NC) Afami-cel

Virtual Mindful After Cancer (MAC) Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors

Early Feasibility Study of the Supira System in Patients Undergoing HRPCI

Global Registry for Endovascular Aortic Treatment (GREAT)