Clinical Trials in Philadelphia

Showing 11941-11960 of 20,904 trials

eCoin Tibial Nerve Stimulation for OAB

NCT03029624

The study is a single arm, prospective study of the safety and effectiveness of the Valencia Technologies eCoin System to stimulate the tibial nerve for the treatment of patients with refractory urgency urinary incontinence.

Urgency Urinary Incontinence

Valencia Technologies Corporation46 participantsStarted Apr 2017

Newport Beach, California, United States • Waterloo, Iowa, United States • Greensboro, North Carolina, United States +4 more locations

COMPLETEDPhase 153 miles

Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors

NCT01596647

This is a multi-center, open-label, phase I study to assess the effects of dovitinib (TKI258) on the pharmacokinetics of a cocktail of caffeine, diclofenac, omeprazole and midazolam in patients with advanced solid tumors, excluding breast cancer. The aim of this study is to evaluate the potential effect of dovitinib (TKI258) on the metabolism of the probe drugs caffeine, diclofenac, omeprazole and midazolam, which are metabolized by CYP1A2, CYP2C9, CYP2C19 and CYP3A4 respectively (Cytochrome P450 isoenzyme), comparing the single-dose pharmacokinetics (AUCtlast, AUCinf and Cmax parameters) of each of the individual probe drug co-administered with and without multiple dose of dovitinib (TKI258) 500 mg under a 5 days on / 2 days off dose schedule. The study foresees two treatment phases: DDI (drug-drug interaction) followed by post-DDI. During the DDI phase patients receive treatment with the probe drug cocktail and dovitinib (TKI258). During the post-DDI phase patients may continue to receive treatment with dovitinib (TKI258) until disease progression (assessed by RECIST 1.1), unacceptable toxicity, death or discontinuation from the study treatment for any other reason.

Advanced Solid Tumors, Excluding Breast Cancer

Novartis Pharmaceuticals39 participantsStarted May 2012

Kansas City, Kansas, United States • Detroit, Michigan, United States • Minneapolis, Minnesota, United States +2 more locations

eCoin Tibial Nerve Stimulation for OAB

Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors

Find Trials by Condition in Philadelphia

NEUWAVE Flex Microwave Ablation System in the Ablation of Primary Soft Tissue Lesions of the Lung

A Biobehavioral Intervention for Young Men With Testicular Cancer

Efficacy 2 Part Study of Identification of Keloid Biomarkers and Effect of QAX576 on Keloid Recurrence

Efficacy of QAX576 in Asthma

Study of Safety and Efficacy of Ribociclib and Trametinib in Patients With Metastatic or Advanced Solid Tumors

Pharmacokinetics and Safety of Single Subcutaneous Pasireotide (SOM230) in Subjects With Varying Degrees of Hepatic Function

Safety and Efficacy Study of Oral Fosfomycin Versus Oral Levofloxacin to Treat Complicated Urinary Syndromes (FOCUS)

A Phase 1 Study of an Investigational Drug, ALN-AT3SC, in Healthy Volunteers and Hemophilia A or B Patients

Phase I/IIa Study of FIXFc in Hemophilia B Patients

Safety of RAD001 in Combination With Cisplatin and Etoposide in Lung Cancer Patients

A Dose-finding Study of a Combination of Imatinib and BKM120 in the Treatment of 3rd Line GIST Patients

Combination of RAD001 and Erlotinib in Patients With Advanced Non Small Cell Lung Cancer Previously Treated Only With Chemotherapy

Impact Of Eplerenone On Cardiovascular Outcomes In Patients Post Myocardial Infarction

Efficacy, Safety, Tolerability, and Pharmacokinetics of Sotrastaurin Combined With Tacrolimus vs. a Mycophenolic Acid-tacrolimus Regimen in Renal Transplant Patients

A Trial l of Panobinostat Given in Combination With Trastuzumab and Paclitaxel in Adult Female Patients With HER2 Positive Metastatic Breast Cancer

PCA062 in pCAD-positive Tumors.

Pharmacokinetics of rFVIIIFc at Two Vial Strengths

A Study to Investigate the Effects of Ketoconazole on LBH589 in Patients With Advanced Solid Tumors