Clinical Trials in Philadelphia

Showing 10181-10200 of 20,904 trials

A Study to Evaluate the Pharmacodynamic Activity of E2730 in Adult Participants With Photosensitive Epilepsy

NCT03603639

The primary purpose of the study is to assess the pharmacodynamic (PD) activity of E2730 as measured by suppression of epileptic photoparoxysmal response (PPR) in the participant's most sensitive eye condition in participants with photosensitive epilepsy.

Photosensitive Epilepsy

Eisai Inc.6 participantsStarted Jul 2018

Little Rock, Arkansas, United States • Boise, Idaho, United States • Baltimore, Maryland, United States +2 more locations

UNKNOWNPhase 2< 1 mile

Intravitreal Aflibercept for the Prevention of Proliferative Vitreoretinopathy Following Retinal Detachment Repair

NCT04580147

The primary objective of the study is to determine if serial intravitreal aflibercept injections (IAI) improve the single surgery anatomic success rate following surgical repair of primary, macula involving rhegmatogenous retinal detachment (RRD) deemed at high risk for proliferative vitreoretinopathy (PVR). Preclinical work has revealed that competitive inhibition of platelet derived growth factor (PDGF) by vascular endothelial growth factor (VEGF) potentiates a pathologic, sustained activation of PDGF receptors that is critical to the progression of experimental PVR. VEGF blockade would mitigate this pathologic activation.

Retinal Detachment With Multiple Breaks, Unspecified EyeProliferative Vitreoretinopathy

M. Ali Khan, MD150 participantsStarted Oct 2020

Philadelphia, Pennsylvania, United States

A Study to Evaluate the Pharmacodynamic Activity of E2730 in Adult Participants With Photosensitive Epilepsy

Intravitreal Aflibercept for the Prevention of Proliferative Vitreoretinopathy Following Retinal Detachment Repair

Find Trials by Condition in Philadelphia

Phase 3 Extension Study of Dexpramipexole in ALS

Optical Measurement of Cerebral Hemodynamics in Children With Acute Arterial Ischemic Stroke

A Study Comparing Vemurafenib Versus Vemurafenib Plus Cobimetinib in Participants With Metastatic Melanoma

Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19

Development of a Next Generation Sequencing (NGS) -Based Assay to Detect Preeclampsia Molecular Markers

Machine Learning Sepsis Alert Notification Using Clinical Data

Efficacy and Safety of Glecaprevir (ABT-493)/Pibrentasvir (ABT 530) (GLE/PIB) in Combination With Sofosbuvir and Ribavirin in Participants With Hepatitis C Virus Who Did Not Respond to Treatment in a Previous AbbVie Clinical Study

Effects of Physical Therapy on Isometric Neck Retraction Strength and Pain in Patients With Neck Disability

Imaging of Coronary Plaques in Participants Treated With Evolocumab

Study of Safety, Tolerability, and Efficacy of a Combination Treatment of LJN452 and CVC in Adult Patients With NASH and Liver Fibrosis

Clinical Investigation to Evaluate the Haemonetics POLFA Modified Sample Needle Assembly With Vacuum Tube Holder

Safety and Biomarker Study of PTC-589 in Participants With Parkinson's Disease

This Was a Dose-finding Study to Evaluate Efficacy and Safety of LOU064 in Patients With CSU Inadequately Controlled by H1-antihistamines

Diffusion MRI-1 Imaging Database

Study of the Safety and Efficacy of MIW815 With PDR001 in Patients With Advanced/Metastatic Solid Tumors or Lymphomas

First-Line Treatment of A Comparison of 2 Treatments in Elderly Patients With Advanced NSCLC

Gene Transfer Clinical Trial for Mucopolysaccharidosis (MPS) IIIB

Steroid Sensitive Nephrotic Syndrome in Children