Clinical Trials in Philadelphia

Showing 1001-1020 of 17,926 trials

Enfortumab Vedotin Schedule De-escalation in Metastatic Urothelial Carcinoma

NCT05923190

This is a non-randomized two arm open-label phase 2 pilot study in adult subjects with locally advanced or metastatic urothelial cancer. The study will investigate an alternative administration schedule of EV given as monotherapy and in combination with pembrolizumab.

Urothelial CarcinomaMetastatic Urothelial CarcinomaLocally Advanced Urothelial Carcinoma

Fox Chase Cancer Center60 participantsStarted Jun 2023

Philadelphia, Pennsylvania, United States

Active Not RecruitingPhase 2< 1 mile

A US Study to Evaluate Transarterial Radioembolization (TARE) in Combination With Durvalumab and Bevacizumab Therapy in People With Unresectable Hepatocellular Carcinoma Amenable to TARE

NCT06040099

The purpose of this study is to measure the efficacy and safety of durvalumab intravenous (IV) solution plus bevacizumab IV solution after transarterial radioembolization (Yttrium 90 glass microspheres TARE) in participants with unresectable hepatocellular carcinoma (HCC) amenable to embolization.

Hepatocellular Carcinoma (HCC)

AstraZeneca58 participantsStarted Feb 2024

Aurora, Colorado, United States • Gainesville, Florida, United States • Orlando, Florida, United States +18 more locations

Enfortumab Vedotin Schedule De-escalation in Metastatic Urothelial Carcinoma

A US Study to Evaluate Transarterial Radioembolization (TARE) in Combination With Durvalumab and Bevacizumab Therapy in People With Unresectable Hepatocellular Carcinoma Amenable to TARE

Find Trials by Condition in Philadelphia

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

Mechanistic Clinical Trial of Colchicine in Patients With Peripheral Artery Disease

A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab

Sense4Safety Intervention

CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis

The Hunger Elimination or Reduction Objective (HERO ) Open -Label Extension (OLE) Trial

Study of Favezelimab Coformulated With Pembrolizumab (MK-4280A) in Participants With Selected Solid Tumors (MK-4280A-010)

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

A Study Called FINE-REAL to Learn More About the Use of the Drug Finerenone in a Routine Medical Care Setting

A Study of the Impact of Endocrine Therapy on Surgical Outcomes in People With Breast Cancer

Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)

A Study to Assess the Efficacy and Safety of Afimkibart (Also Known as RO7790121) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis

Rapid Evacuation and Access of Cerebral Hemorrhage Trial

Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

Evaluation of Efficacy and Safety of THRV-1268 in Long QT Syndrome Type 2 (LQTS 2)

A Study of Pharmacokinetics and Safety of LY3537031 in Participants With Normal Renal Function and Participants With Renal Impairment