Clinical Trials in Philadelphia

Showing 5441-5460 of 20,904 trials

Lentivirally Redirected CD123 Autologous T Cells in AML

NCT03766126

Phase 1 open-label study to estimate the safety, manufacturing feasibility, and efficacy of intravenously administered, lentivirally transduced T cells expressing anti-CD123 chimeric antigen receptors expressing tandem TCRζ and 4-1BB (TCRζ /4-1BB) costimulatory domains in Acute Myeloid Leukemia (AML) subjects.

Acute Myeloid Leukemia, in RelapseAcute Myeloid Leukemia, AdultAcute Myeloid Leukemia, Refractory

University of Pennsylvania22 participantsStarted Dec 2018

Philadelphia, Pennsylvania, United States

Active Not RecruitingPhase 1< 1 mile

Up-front CART-BCMA With or Without huCART19 in High-risk Multiple Myeloma

NCT03549442

This is an open-label phase 1 study to assess the safety and pharmacodynamics of CART-BCMA, with or without huCART19, in patients responding to first- or second-line therapy for high-risk multiple myeloma. The regimen evaluated in this study is based on established safety of CARTBCMA demonstrated in UPCC 14415/IRB#822756 at dose of 5x108 cells, administered as split infusions, following cyclophosphamide 1.5 g/m2 in patients with relapsed/refractory myeloma. This study tests CART-BCMA (1) as consolidation of early therapy for multiple myeloma, (2) with addition of fludarabine to the lymphodepleting chemotherapy regimen, (3) in combination with huCART19, and (4) as a single rather than split-dose infusion.

Multiple Myeloma

University of Pennsylvania40 participantsStarted May 2018

Philadelphia, Pennsylvania, United States

Lentivirally Redirected CD123 Autologous T Cells in AML

Up-front CART-BCMA With or Without huCART19 in High-risk Multiple Myeloma

Find Trials by Condition in Philadelphia

Post-Approval Study of the TREO Abdominal Stent-Graft System

Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Bowel

A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy

Study of V117957 in Overactive Bladder Syndrome

Efficacy, Safety, and PK of LX9211 in Participants With Diabetic Peripheral Neuropathic Pain

A Study to Assess Stroke Risk Among Users of Typical Versus Atypical Antipsychotics Stratified by Broad Age Group

A Study on Suicidality, Psychosis or Substance Abuse With Methylphenidate, Atomoxetine, Amphetamine/Dextroamphetamine or Lisdexamfetamine

A Study of Fluoroquinolones Exposure and Collagen-Related Serious Adverse Events

A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease

Apixaban for the Treatment of Venous Thromboembolism in Patients With Cancer

A Study of DS-8201a in Metastatic Breast Cancer Previously Treated With Trastuzumab Emtansine (T-DM1)

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain

International Rare Histiocytic Disorders Registry (IRHDR)

DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors

Trial to Evaluate the Safety and Pharmacokinetics of HMPL-689 in Patients With Lymphomas

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Participants With Advanced Solid Tumors

Implementing Precision Medicine in cOmmunity HospiTALs