Clinical Trials in Philadelphia

Showing 5081-5100 of 20,904 trials

Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease

NCT06345638

This study aims to characterize sex differences in the pathophysiology of vaso-occlusive crises (VOC) occurring among individuals with sickle cell disease (SCD). * The study will compare CRP and other biomarkers between females with SCD in the follicular phase of the menstrual cycle and males with SCD. * The study will explore potential sex differences in biomarker changes between females and males with SCD during and following resolution of VOC. * The study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood.

Sickle Cell DiseaseVaso-occlusive Crisis

University of Pennsylvania52 participantsStarted Mar 2024

Philadelphia, Pennsylvania, United States • Philadelphia, Pennsylvania, United States • Philadelphia, Pennsylvania, United States

TERMINATEDPhase 3< 1 mile

OPT-302 With Aflibercept in Neovascular Age-related Macular Degeneration (nAMD)

NCT04757636

A 2-year phase 3, multicentre, randomised, parallel-group, sham-controlled, double-masked study. Primary efficacy will be determined at Week 52.

Neovascular Age-related Macular Degeneration

Opthea Limited998 participantsStarted Mar 2021

Phoenix, Arizona, United States • Arcadia, California, United States • Huntington Beach, California, United States +206 more locations

Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease

OPT-302 With Aflibercept in Neovascular Age-related Macular Degeneration (nAMD)

Find Trials by Condition in Philadelphia

Study of Venetoclax in Combination With Carfilzomib and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma (MM)

A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433

Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

RISE FOR HEALTH Study

Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DME (ASPIRE)

A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Upadacitinib in Pediatric Subjects With Polyarticular Course Juvenile Idiopathic Arthritis

SAR408701 Versus Docetaxel in Previously Treated, Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small-cell Lung Cancer Patients

Connect® MM- The Multiple Myeloma Disease Registry

A Prospective Cohort Post Market Registry Evaluating Outcomes of Bridge-Enhanced ACL Restoration (BEAR®)

A Comparison of PT027 vs PT007 Used as Needed in Participants With Asthma

Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Relapsed or Refractory Advanced Non-Small Cell Lung Cancer With an FGFR Alteration

Clinical Significance of Germline BRCA Mutations

Radiofrequency Ablation of Atrial Fibrillation Under Apnea

A Study to Compare the Efficacy and Safety of JCAR017 to Standard of Care in Adult Subjects With High-risk, Transplant-eligible Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphomas

Enhancing Engagement With Digital Mental Health Care

A Study of INCB099280 in Combination With Adagrasib in Adults With Advanced Solid Tumors Harboring a KRASG12C Mutation

Study of Inupadenant (EOS100850) With Chemotherapy as Second Line Treatment for Nonsquamous Non-small Cell Lung Cancer

A Study to Evaluate the Pharmacokinetics and Safety of INCB054707 in Participants With Normal Hepatic Function and Participants With Hepatic Impairment