Clinical Trials in Philadelphia

Showing 4181-4200 of 20,904 trials

Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer

NCT06436248

The overall goal of the Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer (PROMISE) study is to better understand how women may incorporate both polygenic risk score (PRS) and novel early detection strategies in their decisions regarding cancer screening and risk reducing surgery. This study will conduct qualitative interviews to better understand women's attitudes regarding polygenic risk score (PRS) and early detection assays.

Ovarian CancerBRCA Mutation

Abramson Cancer Center at Penn Medicine24 participantsStarted Jul 2024

Philadelphia, Pennsylvania, United States

Active Not RecruitingPhase 1/2< 1 mile

Safety, Tolerability, and Exploratory Efficacy Study of Intrathecally Administered Gene Therapy AMT-162 in Adult Participants With SOD1 Amyotrophic Lateral Sclerosis (SOD1-ALS)

NCT06100276

This is the study of AMT-162 in Participants with SOD1-ALS and is designed to evaluate the safety, tolerability, and exploratory efficacy of intrathecally administered gene therapy AMT-162. AMT-162-001 is a Phase 1/2, multi-center, single ascending dose study.

Amyotrophic Lateral Sclerosis

UniQure Biopharma B.V.20 participantsStarted Aug 2024

Phoenix, Arizona, United States • Irvine, California, United States • San Francisco, California, United States +9 more locations

Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer

Safety, Tolerability, and Exploratory Efficacy Study of Intrathecally Administered Gene Therapy AMT-162 in Adult Participants With SOD1 Amyotrophic Lateral Sclerosis (SOD1-ALS)

Find Trials by Condition in Philadelphia

Extension Study to Evaluate Safety and Efficacy of CTP-543 in Adults With Alopecia Areata

Intrahepatic Delivery of SD-101 by Pressure-Enabled Regional Immuno-oncology (PERIO), With Checkpoint Blockade in Adults With Metastatic Uveal Melanoma

A Study of Olezarsen Administered Subcutaneously to Participants With Severe Hypertriglyceridemia

Trial of Indication-Based Transfusion of Red Blood Cells in ECMO

Nonhealing Diabetic Foot Ulcers Treated With Standard of Care (SOC) Alone or Standard of Care and Amnion-Intermediate-Chorion (AIC)

Azacitidine Combined With Pembrolizumab and Epacadostat in Subjects With Advanced Solid Tumors (ECHO-206)

PMT for MDRO Decolonization

Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036)

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC

A Study of Sotorasib (AMG 510) in Participants With Stage IV NSCLC Whose Tumors Harbor a KRAS p.G12C Mutation in Need of First-line Treatment

Combined AlloStim+Anti-PD-L1 in 4L MSS Metastatic Colorectal Cancer

Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)

CAMP RWE Trial: Amnion Grafts for Healing Hard-to-Heal Ulcers in RW Populations

Real-World Patient Experiences Using Continuous Subcutaneous Apomorphine Infusion (ONAPGOTM) in the United States:

A Study to Learn How Well the Study Treatment Finerenone Works and How Safe it is in People With Long-term Decrease in the Kidneys' Ability to Work Properly (Chronic Kidney Disease) Together With Type 1 Diabetes

Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty