Clinical Trials in Philadelphia

Showing 2401-2420 of 17,926 trials

Functional Lung Avoidance Radiation Therapy Using Hyperpolarized Xenon-129 MRI

NCT05302817

Cancer radiation treatment plans that employ lung functional avoidance methods require 3D maps that differentiate regions of healthy lung function from regions of compromised tissue to deliver sufficient dose to the tumor while preserving as much functioning lung as possible. Hyperpolarized xenon-129 MRI can provide maps of ventilatory function and gas exchange to the bloodstream. Improving treatment plans based on this novel imaging modality could reduce risk or severity of radiation pneumonitis and improve post-treatment quality of life.

Carcinoma, Non-Small-Cell Lung

Xemed LLC9 participantsStarted Mar 2023

Philadelphia, Pennsylvania, United States

Active Not RecruitingPhase 3< 1 mile

Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency

NCT04493853

This study will assess the efficacy and safety of capivasertib plus abiraterone (+prednisone/prednisolone) plus androgen deprivation therapy (ADT) versus placebo plus abiraterone (+prednisone/prednisolone) plus ADT in participants with mHSPC whose tumours are characterised by PTEN deficiency. The intention of the study is to demonstrate that in participants with mHSPC, the combination of capivasertib plus abiraterone (+prednisone/prednisolone) plus ADT is superior to placebo plus abiraterone (+prednisone/prednisolone) plus ADT in participants with mHSPC characterised by PTEN deficiency with respect to radiographic progression-free survival (rPFS) per 1) Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 for soft tissue and/or Prostate Cancer Working Group (PCWG3) for bone as assessed by the investigator 2) death due to any cause.

Hormone-Sensitive Prostate Cancer

AstraZeneca1,012 participantsStarted Jul 2020

Tucson, Arizona, United States • Tucson, Arizona, United States • La Jolla, California, United States +320 more locations

Functional Lung Avoidance Radiation Therapy Using Hyperpolarized Xenon-129 MRI

Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency

Find Trials by Condition in Philadelphia

Tau PET Imaging in Opioid Use Disorder

Acute Effects of Ketone Supplement on Responses to Alcohol Challenge in Healthy Volunteers

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

Efficacy and Safety of Erenumab in Pediatric Subjects With Chronic Migraine

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Interventional Study of Vosoritide for the Treatment of Children With Hypochondroplasia

Unresectable Stage IIIA/IIIB Non-small Cell Lung Cancer (NSCLC)

A Study of HB-202/HB-201 in People With Human Papilloma Virus 16-Positive Head and Neck Squamous Cell Cancer (HPV 16+ HNSCC)

A Study of Stereotactic Radiosurgery (SRS) to Treat Pain in the Chest and/or Stomach Wall

A Study to Determine if BHV-7000 is Effective and Safe in Adults With Idiopathic Generalized Epilepsy With Generalized Tonic-clonic Seizures

A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis

Losartan to Improve Outcomes After Multi-ligament Knee Injury

A Study of Tiragolumab in Combination With Atezolizumab in Chemotherapy-Naïve Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Expanded Access Protocol for Boys With Duchenne Muscular Dystrophy

Evaluation of the Efficacy and Safety of Magnetic Resonance Angiography (MRA) Using Gadopiclenol Compared to Gadoterate Meglumine in the Assessment of Steno-occlusive Disease in Adult Patients With Suspected Vascular Disease