Clinical Trials in Philadelphia

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Adaptive Phase I HCV Study With Nucleoside Analogue, in Combination With Interferon and Ribavirin

NCT00382798

This is an adaptive Phase I study to evaluate RO5024048 in the following groups: * Healthy Volunteers (Part 1 - Single Ascending Dose Study) -Enrollment completed * Hepatitis C virus (HCV) genotype 1 infected patients who have failed interferon therapy (Part 2- Multiple Ascending Dose Study)-Enrollment Completed * HCV genotype 1-infected patients who are treatment naive, to be dosed in combination with PEG-IFN and RBV (Part 3 - Combination Dose Study)-Currently Enrolling * HCV genotype 2-3 infected patients who have previously been treated with interferon but who did not respond, to be dosed in combination with PEG-IFN and RBV (Part 3 - Combination Dose Study)- Currently enrolling The study aims to determine if RO5024048 is safe and well-tolerated in healthy people and in people infected with hepatitis C virus. The amount of RO5024048 in the blood will be measured during the study and the amount of hepatitis C virus in the blood after each dose will also be measured. During Part 3 of the study, RO5024048 will be given with PEG-IFN and RBV, two drugs currently used and approved for the treatment of HCV.

Healthy VolunteersHepatitis C Virus

Pharmasset75 participantsStarted Oct 2006

San Francisco, California, United States • Aurora, Colorado, United States • Gainesville, Florida, United States +6 more locations

COMPLETEDNA< 1 mile

Study of Two Surgical Approaches for Total Hip Arthroplasty

NCT00881998

A prospective, comparative, randomized single surgeon study comparing minimally invasive total hip arthroplasty (MIS) via anterior approach to conventional total hip arthroplasty via anterolateral transgluteal approach.

Total Hip Arthroplasty

Rothman Institute Orthopaedics100 participants

Philadelphia, Pennsylvania, United States

Adaptive Phase I HCV Study With Nucleoside Analogue, in Combination With Interferon and Ribavirin

Study of Two Surgical Approaches for Total Hip Arthroplasty

Find Trials by Condition in Philadelphia

Study Comparing STR (Skeletal Targeted Radiotherapy) Plus Melphalan to Melphalan Alone, With Stem Cell Transplant in Multiple Myeloma

Study of Anginera in Adults With a Left Ventricular Assist Device (LVAD) as Bridge to Transplant

Phase 3 /Seroquel SR Acute Mania Monotherapy - US

Study of MEDI-522 Administered by Subcutaneous Injection to Adults With Plaque Psoriasis

Obese Patients With Type 2 Diabetes

Efficacy and Safety of Zolpidem-MR Administered Over a Long Term Period as Needed for Insomnia (ZOLONG)

NEXIUM® in the Treatment of Moderate and Severe Erosive Esophagitis

Efficacy of Ciclesonide Versus Placebo Administered Either as Once Daily or Twice Daily in Patients Treated Previously With an Inhaled Corticosteroid

Efficacy and Safety of Rimonabant on Weight Loss and Frequency of Binge Episodes in Obese Patients

Study Evaluating Rimonabant Efficacy in Insulin-Treated Diabetic Patients(ARPEGGIO)

Efficacy and Safety of Rimonabant as an Aid to Maintenance of Smoking Cessation

An International Study of Rimonabant in Dyslipidemia With AtheroGenic Risk In Abdominally Obese Patients

TELI TON - Telithromycin in Tonsillitis

Prospective Evaluation of the Fluid Rapid Influenza Test

Pharmacokinetic Study of Vildagliptin in Patients With Renal Impairment

Evaluation of Efficacy and Safety of an Anti-Allergy Drug With a Contact Lens in the Treatment of Allergic Conjunctivitis

GALLANT 14 Tesaglitazar vs. Metformin and Fenofibrate

A Study to Evaluate NBI-6024 in Adult and Adolescent Patients With New Onset of Type 1 Diabetes Mellitus