Clinical Trials in Pennsylvania

Showing 14621-14640 of 19,675 trials

A Phase 1b Study to Assess the Safety and Anti-inflammatory Effects of Two Different Doses of SRT2104 in Patients With Ulcerative Colitis

NCT01453491

The purpose of this research study is to: * 1\) Test the safety and tolerability of 2 different oral doses of SRT2104 in subjects with ulcerative colitis * 2\) Determine the amount of SRT2104 measured from a single blood sample in addition to colon and/or rectal tissue samples (biopsies) * 3\) Determine whether SRT2104 has any anti-inflammatory effect on the colon and/or rectum when taken orally for 8 weeks * 4\) Determine whether SRT2104 causes any detectable changes to specific biomarkers. A biomarker is a biological marker (or substance such as a protein) that is used as an indicator of changes in a biological state that corresponds to the risk or progression of a disease.

Colitis, Ulcerative

Sirtris, a GSK Company17 participantsStarted Feb 2012

Anaheim, California, United States • Bristol, Connecticut, United States • Owensboro, Kentucky, United States +10 more locations

COMPLETEDPhase 295 miles

A Phase 2, Multicenter, Open-label Study of MEDI-551 in Adults With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

NCT01466153

The overall purpose of the study was to determine if MEDI-551, when used in combination with salvage chemotherapy (bendamustine) in participants with relapsed or refractory CLL who are not eligible for Autologous Stem Cell Transplant (ASCT), had superior efficacy compared to rituximab in the same population.

Chronic Lymphocytic Leukemia (CLL)

MedImmune LLC183 participantsStarted Feb 2012

Birmingham, Alabama, United States • Burbank, California, United States • La Jolla, California, United States +51 more locations

A Phase 1b Study to Assess the Safety and Anti-inflammatory Effects of Two Different Doses of SRT2104 in Patients With Ulcerative Colitis

A Phase 2, Multicenter, Open-label Study of MEDI-551 in Adults With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

Find Trials by Condition in Pennsylvania

Monitoring Disease Activity Using Video Capsule Endoscopy (VCE) in Crohn's Disease (CD) Subjects

Sexual Functioning Study With Antidepressants

Lethargic Depression Study

Phase III Randomized Study of SYNSORB Pk in Children With E. Coli-Associated Hemolytic Uremic Syndrome

Bisphosphonate Treatment of Osteogenesis Imperfecta

Multi-center Study of Myeloablative Allo Stem Cell Transplant for Non-remission AML Using CloBu4 Regimen

A Bioequivalence Study of Two Oral Formulations of Topotecan in Patients With Advanced Solid Tumors

PK Study of Dapagliflozin in Pediatric Subjects With T2DM

GW873140 In Combination With Combivir In HIV Infected Subjects

A Prospective Study to Collect High-Quality Documentation of Bleeds, Health-Related Quality of Life (HRQoL), and Safety Outcomes in Patients With Hemophilia A Treated With Standard-of-Care Treatment

Covered Metallic Stents for First-Line Treatment of Benign Bile Duct Strictures

A Phase II Trial of Ofatumumab in Subjects With Waldenstrom's Macroglobulinemia

Endoscopic Resection or Ablation for Patients With Dysplasia or Cancer Requiring Treatment of Barrett's Esophagus

Efficacy of Prednisone In the Treatment of Ocular Myasthenia

Pivotal, Multicenter, Observer-Blind, Randomized Study of Influenza A (H1N1)2009 Monovalent Subunit Vaccine With and Without Adjuvant in Children Ages 6 to <36 Months

Observational Study Of A Protease Inhibitor (PI) Containing Regimen In Subjects With PI Mutations Selected During Prior Treatment With GW433908 (Fosamprenavir)

A Long Term Safety Study of Mavrilimumab in Adult Subjects With Rheumatoid Arthritis

BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis