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Clinical Trials in Pennsylvania | 19,675 Studies Near You | Clareo Health

Clinical Trials LocationsPennsylvania

Clinical Trials in Pennsylvania

Discover 19,675 clinical trials near Pennsylvania. Find research studies in your area.

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Showing 13701-13720 of 19,675 trials

COMPLETEDNA37 miles

Clinical Performance Comparison of Two Contact Lenses

NCT00975585

The purpose of this study is to compare the clinical performance of two contact lenses.

Johnson & Johnson Vision Care, Inc.379 participantsStarted Aug 2009

North Little Rock, Arkansas, United States • Campbell, California, United States • Colorado Springs, Colorado, United States +22 more locations

COMPLETEDNA37 miles

Vistakon Investigational Multi-purpose Contact Lens Care Solution.

NCT01055457

This study compares an investigational contact lens care multi-purpose solution to a currently marketed multi-purpose solution.

Contact Lens Wear

Johnson & Johnson Vision Care, Inc.315 participantsStarted Nov 2009

Mission Viejo, California, United States • Orlando, Florida, United States • Tallahassee, Florida, United States +11 more locations

Find Trials by Condition in Pennsylvania

Breast Cancerin Pennsylvania Lung Cancerin Pennsylvania Prostate Cancerin Pennsylvania Colorectal Cancerin Pennsylvania Melanomain Pennsylvania Leukemiain Pennsylvania Lymphomain Pennsylvania Pancreatic Cancerin Pennsylvania Ovarian Cancerin Pennsylvania Brain Cancerin Pennsylvania

Data from ClinicalTrials.govTerms

COMPLETEDNA61 miles

Acute Study to Collect Electrical Signals From the Heart Using a Special Lead

NCT02772380

The main purpose of this clinical study is to collect electrograms from an investigational lead placed in an extravascular space, for development of a future Implantable Cardioverter Defibrillator (ICD) system.

TachycardiaVentricular Arrhythmias

Medtronic Cardiac Rhythm and Heart Failure87 participantsStarted May 2016

Scottsdale, Arizona, United States • Hartford, Connecticut, United States • Jacksonville, Florida, United States +33 more locations

COMPLETEDNA83 miles

Dispensing Evaluation of Subjective Comfort, Vision, and Handling of a New Lens Compared to a Marketed Lens

NCT01484054

To evaluate and compare the performance of a new contact lens to a marketed contact lens.

Refractive Ametropia

Johnson & Johnson Vision Care, Inc.103 participantsStarted Nov 2011

Bloomfield, Connecticut, United States • Tallahassee, Florida, United States • Overland Park, Kansas, United States +3 more locations

COMPLETEDPhase 495 miles

A Comparator Study of Fluticasone Propionate Nasal Spray Verses (vs) Cetirizine in the Treatment of Seasonal Allergic Rhinitis

NCT01916226

This phase IV investigational trial is being conducted to evaluate the efficacy of a 2-week treatment of fluticasone propionate nasal spray (FPNS) vs. cetirizine on allergic nasal and ocular symptoms and quality of life in adult subjects with SAR. It is hypothesized that FPNS provides greater nasal symptom relief than cetirizine. The primary measure used to test this hypothesis is the change from baseline over two weeks in reflective total nasal symptom score (rTNSS) compared between FPNS and cetirizine. Approximately 648 subjects will be randomized into a 1:1:1:1 ratio of treatment allocation across approximately twenty-five to thirty-five sites in the US during the 2013 fall allergy season. All subjects will be outpatients. The total duration of study will be approximately 21 days including 7 days of screening period, and 14 days of treatment period.

Rhinitis, Allergic, Perennial and Seasonal

GlaxoSmithKline682 participantsStarted Aug 2013

Little Rock, Arkansas, United States • Denver, Colorado, United States • Aventura, Florida, United States +28 more locations

COMPLETEDNA117 miles

Non-Invasive Neurostimulation for the Prevention of Chronic Migraine

NCT01667250

The purpose of this multi-center, prospective, double-blind, randomized, sham-controlled pilot study is to study feasibility and collect preliminary clinical data related to the safety and clinical benefits of daily use of non-invasive vagal nerve stimulation with the GammaCore device for the prevention of chronic migraine, and to support the development and approval of a larger pivotal study.

Chronic Migraine

ElectroCore INC59 participantsStarted Oct 2012

San Francisco, California, United States • Ann Arbor, Michigan, United States • Springfield, Missouri, United States +3 more locations

COMPLETED118 miles

Daily Disposable Performance of 1•DAY ACUVUE® TruEye™ and 1•DAY ACUVUE® MOIST® With LACREON® TECHNOLOGY

NCT01467557

This study is an observational registry of patients who have recently been prescribed 1•DAY ACUVUE® TruEye® or 1•DAY ACUVUE® MOIST® Brand Contact Lenses with LACREON® TECHNOLOGY.

MyopiaHyperopia

Johnson & Johnson Vision Care, Inc.1,171 participantsStarted Oct 2011

Campbell, California, United States • Fullerton, California, United States • Huntington Beach, California, United States +34 more locations

COMPLETEDPhase 3118 miles

Phase 3 Study to Evaluate Safety and Efficacy of Iclaprim Versus Vancomycin for ABSSSI: REVIVE-1

NCT02600611

This is a multicenter, randomized, double-blind study of the efficacy and safety of iclaprim compared to vancomycin for the treatment of skin and skin structure infections.

Skin Structures and Soft Tissue Infections

Motif Bio600 participantsStarted Nov 2015

Buena Park, California, United States • La Mesa, California, United States • Long Beach, California, United States +53 more locations

COMPLETEDNA119 miles

Evaluation of the Performance of Two Contact Lenses Compared to a Marketed Lens

NCT01484028

This study will serve to evaluate and compare the performance of two new lenses to a marketed lens.

Refractive Ametropia

Johnson & Johnson Vision Care, Inc.275 participantsStarted Nov 2011

Mission Viejo, California, United States • Mission Viejo, California, United States • Pismo Beach, California, United States +12 more locations

COMPLETEDNA119 miles

Clinical Evaluation of Lapsed Contact Lens Wearers Who Are Re-fit Into Senofilcon A Contact Lenses

NCT01990664

This study is an open-label, multi-site study. The total number of subjects was 200. The duration of this study was approximately four weeks. The primary objective was to assess what percentage of lapsed contact wearers, who have discontinued use of their contact lenses for greater than six months can be successfully re-fit with senofilcon A, reusable 2-weekly replacement daily wear lenses (spherical and toric designs).

Lapsed Contact Lens Wear

Johnson & Johnson Vision Care, Inc.199 participantsStarted Nov 2013

Jacksonville, Florida, United States • Saint Augustine, Florida, United States • Sarasota, Florida, United States +7 more locations

COMPLETEDNA119 miles

Comparison of Two Daily Disposable Contact Lenses Over 1-week of Wear

NCT01669629

This is a one week 2x2 crossover study comparing delefilcon A with etafilcon A, with a primary hypothesis of comparing the handling of each lens. Additional secondary markers are measured looking at subjective comfort and vision of the lenses.

Johnson & Johnson Vision Care, Inc.183 participantsStarted Aug 2012

Little Rock, Arkansas, United States • Bridgeport, Connecticut, United States • Tampa, Florida, United States +7 more locations

COMPLETEDNA122 miles

Clinical Evaluation of a Multifocal Contact Lens on Symptomatic Patients

NCT01016652

The purpose of this study is to evaluate the effect of a multi-focal contact lens on symptomatic patients.

Johnson & Johnson Vision Care, Inc.49 participantsStarted Oct 2009

North Little Rock, Arkansas, United States • Blue Springs, Missouri, United States • Lake Ozark, Missouri, United States +5 more locations

COMPLETEDPhase 2124 miles

Safety, Tolerability and Efficacy of ISIS-GCGRRx in Patients With Type 2 Diabetes

NCT02583919

The purpose of this study is to evaluate the efficacy, safety, and tolerability of ISIS-GCGRRx in combination with metformin versus placebo

Type 2 Diabetes

Ionis Pharmaceuticals, Inc.79 participantsStarted Sep 2015

Greenbrae, California, United States • Huntington Park, California, United States • La Mesa, California, United States +16 more locations

COMPLETEDPhase 3147 miles

Chemotherapy After Prostatectomy (CAP) For High Risk Prostate Carcinoma

NCT00132301

VA Cooperative Study #553 is designed to prospectively evaluate the efficacy of early adjuvant chemotherapy using docetaxel and prednisone added to the standard of care for patients who are potentially cured by radical prostatectomy but who are at high risk for relapse. The standard of care is surveillance, with the addition of androgen deprivation at the time of biochemical relapse. This study will assess the effect of adding early chemotherapy to the standard of care on progression free survival in Veterans at high risk for progression after prostatectomy.

Prostate Cancer

VA Office of Research and Development298 participantsStarted Jun 2006

Birmingham, Alabama, United States • Tucson, Arizona, United States • North Little Rock, Arkansas, United States +31 more locations

COMPLETEDPhase 4158 miles

Ethanol-Free Clobetasol Propionate Foam 0.05% (Olux-E Foam) vs Vehicle Foam in the Treatment of Chronic Hand Dermatitis.

NCT01323673

The purpose of this study is to determine how clobetasol proprionate foam works against a placebo foam in the treatment of hand dermatitis.

Dermatitis, Chronic

Stiefel, a GSK Company125 participantsStarted Nov 2010

San Diego, California, United States • Boynton Beach, Florida, United States • West Palm Beach, Florida, United States +7 more locations

COMPLETEDPhase 1167 miles

A Study Evaluating the Safety and Pharmacokinetics of DMUC4064A in Participants With Platinum-Resistant Ovarian Cancer or Unresectable Pancreatic Cancer

NCT02146313

This is a Phase 1, multicenter, open-label, dose-escalation study of DMUC4064A administered by intravenous (IV) infusion every three weeks (q3w) to cancer participants. The study will employ a traditional 3 + 3 dose escalation design to determine the maximum tolerated dose (MTD) of DMUC4064A against platinum-resistant ovarian cancer. Once a q3w recommended Phase 2 dose (RP2D) is identified, two expansion cohorts (one in platinum-resistant ovarian cancer and another in unresectable pancreatic cancer) may be evaluated to further characterize the safety and activity in these populations.

Pancreatic NeoplasmsOvarian Neoplasms

Genentech, Inc.35 participantsStarted Jun 2014

Sarasota, Florida, United States • Boston, Massachusetts, United States • Boston, Massachusetts, United States +4 more locations

COMPLETEDNA168 miles

Evaluation of Etafilcon A Daily Disposable Lenses

NCT02061592

To evaluate the clinical performance of daily disposable etafilcon A lenses.

Johnson & Johnson Vision Care, Inc.136 participantsStarted Jan 2014

Jacksonville, Florida, United States • Honolulu, Hawaii, United States • Kahului, Hawaii, United States +4 more locations

COMPLETEDPhase 4176 miles

A Fixed Dose, Dose Response Study for Ropinirole Prolonged Release in Patients With Early Stage Parkinson's Disease

NCT01485172

This study is a fixed dose, dose response study to characterize the dose response for ropinirole PR in early stage PD patients (Hoehn \& Yahr stages I-III). After screening and baseline assessments, subjects will be randomized to one of six final target treatment groups (placebo, 2, 4, 8, 12 or 24mg/day ropinirole PR). The study will consist of a screening period, an up-titration period, a maintenance period, a down titration period and a follow up period. This study utilizes change from baseline in the UPDRS motor score as the primary endpoint, in line with that used in the ropinirole PR monotherapy pivotal study (SK\&F101468/168). Clinical review of the primary and secondary endpoints will be performed in order to establish the lowest maximally effective therapeutic dose.

Parkinson Disease

GlaxoSmithKline186 participantsStarted Jan 2012

Fountain Valley, California, United States • Pasadena, California, United States • Reseda, California, United States +31 more locations

COMPLETEDPhase 3216 miles

A Safety Study of Intravenous Pro-Netupitant and Palonosetron Combination for the Prevention of Nausea and Vomiting

NCT02517021

NEPA-15-18 is a clinical study assessing safety of pro-netupitant and palonosetron, two antiemetic drugs, given with oral dexamethasone. The objective of the study is to evaluate if pro-netupitant and palonosetron are safe when administered to prevent nausea and vomiting after administration of repeated cycles of chemotherapy.

Chemotherapy-Induced Nausea and Vomiting

Helsinn Healthcare SA405 participantsStarted Nov 2015

Santa Monica, California, United States • Whittier, California, United States • Grand Junction, Colorado, United States +71 more locations

COMPLETEDNA257 miles

Pilot Evaluation of a New Galyfilcon A Lens Prototype and Enfilcon A Lens

NCT01192542

The purpose of this study is to compare the visual acuity, limbal and bulbar redness of the new galyfilcon A prototype lenses against Avaira® lenses when worn as daily wear for seven (7) days.

Johnson & Johnson Vision Care, Inc.39 participantsStarted Aug 2010

Pismo Beach, California, United States • Warwick, Rhode Island, United States • Fincastle, Virginia, United States

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