Clinical Trials in Pennsylvania

Showing 5481-5500 of 19,675 trials

A Study of AG-348 in Adult Participants With Pyruvate Kinase (PK) Deficiency

NCT02476916

Study AG348-C-003 is a multicenter study designed to evaluate the safety and efficacy of different dose levels of AG-348 (mitapivat) in participants with PK deficiency.

Pyruvate Kinase Deficiency

Agios Pharmaceuticals, Inc.52 participantsStarted Jun 2015

Palo Alto, California, United States • Boston, Massachusetts, United States • Detroit, Michigan, United States +10 more locations

RECRUITINGNA40 miles

Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement

NCT04732962

Osteoarthritis (OA), the most common type of arthritis, affects more than 32.5 million adults in the United States. It is also among the most expensive condition to treat when joint replacement surgery is required. Although biomechanics plays an important role in OA disease, the non-surgical treatment options addressing biomechanics are scarce with limited effect. AposHealth is the fist biomechanical treatment that was shown to have a significant short-term effect on patients with knee OA. The main objectives of this study are: 1. To assess AposHealth, a non-invasive home-based biomechanical treatment, as an alternative treatment for patients who are eligible for Total Knee Replacement (TKR). 2. To assess AposHealth as a new post-operative rehabilitation tool for patients post TKR.

Osteoarthritis, Knee

Geisinger Clinic150 participantsStarted Jul 2021

Danville, Pennsylvania, United States • Wilkes-Barre, Pennsylvania, United States

A Study of AG-348 in Adult Participants With Pyruvate Kinase (PK) Deficiency

Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement

Find Trials by Condition in Pennsylvania

A Study to Evaluate the Efficacy and Safety of VIB4920 in Participants With Sjögren's Syndrome

Safety, Tolerability and Efficacy of ACZ885 on Leg Artery Structure in Patients With Peripheral Artery Disease

A Study Comparing Daratumumab, Lenalidomide, and Dexamethasone With Lenalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children

The ENERGY 3 Study: Evaluation of Efficacy and Safety of INZ-701 in Children With ENPP1 Deficiency

A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced Interbody Cages in the Lumbar Spine

Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep Apnea

ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR: SOCRATES

Defining ctDNA Metrics in Posttransplant Lymphoproliferative Disorder (PTLD)

A Study of Encapsulated Cell Technology (ECT) Implant for Participants With Early Stage Retinitis Pigmentosa

TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps

Continued Access of Focal MR-Guided Focused Ultrasound for Localized Intermediate Risk Prostate Lesions

Study of AGEN1571 in Participants With Advanced Solid Tumors

Targeting Attention Orienting to Social Threat to Reduce Social Anxiety in Youth

Zibotentan and Dapagliflozin in Patients With Type 2 Diabetes and Elevated Albuminuria

Expanded Access for Cancer Treatment With Balstilimab (AGEN2034) and Zalifrelimab (AGEN1884)

A Digital Intervention to Improve Physical Activity and Sleep Behaviors in Youth With Psychiatric Diagnoses

An Investigation to Validate Speech Perception Assessment for Adult Cochlear Recipients Using a Mobile Research App