Clinical Trials in Pennsylvania

Showing 4201-4220 of 19,675 trials

Use of Nicotine Pouches Among Daily Smokers

NCT06043362

The purpose of this clinical trial is to understand the health effects of a new oral nicotine pouch, and also to understand if this product can help reduce traditional cigarette smoking. The main aims are: 1. Understand the impact of nicotine pouch use on toxicant exposure biomarkers, and indicators of potential harms to health. 2. Examine the influence of nicotine pouch use on conventional tobacco product use (cigarettes). Participants will be randomized to one of six nicotine pouch groups (3 nicotine strengths, each with 2 potential flavors) to use over 16 weeks and asked to reduce their cigarette smoking over that time by at least 75% by substituting with the use of the nicotine pouches. Researchers will compare the outcomes of the different nicotine pouch strengths and flavors to each other. Participants will be asked to complete study questionnaires and provide urine, exhaled carbon monoxide, and mouth cell samples, and other health measurements.

Tobacco Dependence

Milton S. Hershey Medical Center375 participantsStarted Sep 2024

Hershey, Pennsylvania, United States • Houston, Texas, United States

COMPLETEDPhase 236 miles

Study of TTI-101 in Participants With Idiopathic Pulmonary Fibrosis

NCT05671835

The primary objective of this study is to evaluate the safety and tolerability of oral daily administration of TTI-101 over a 12-week treatment duration in participants with idiopathic pulmonary fibrosis (IPF).

Idiopathic Pulmonary Fibrosis

Tvardi Therapeutics, Incorporated100 participantsStarted May 2023

Birmingham, Alabama, United States • La Jolla, California, United States • Orange, California, United States +25 more locations

Use of Nicotine Pouches Among Daily Smokers

Study of TTI-101 in Participants With Idiopathic Pulmonary Fibrosis

Find Trials by Condition in Pennsylvania

Efficacy and Safety of Losmapimod in Treating Subjects With Facioscapulohumeral Muscular Dystrophy (FSHD) With Open-Label Extension (OLE)

Cisplatin vs Paclitaxel for Triple Negative Breast Cancer

A Study to Assess Collagenase Clostridium Histolyticum (CCH) in the Treatment of Plantar Fasciitis (PFA)

Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)

Study of AC699 in Patients With Estrogen Receptor Positive/Human Epidermal Growth Factor Receptor 2 Negative (ER+/HER2-) Locally Advanced or Metastatic Breast Cancer

Open-label Study of Adjunctive GNX Treatment in Children and Adults With TSC-related Epilepsy

Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

Cabozantinib S-Malate in Treating Patients With Recurrent or Metastatic Endometrial Cancer

Radiation, Immunotherapy and PARP Inhibitor in Triple Negative Breast Cancer

A Randomized, Double-Blind Phase II Study of Adjuvant Pembrolizumab Versus Placebo in Head and Neck Cancers at High Risk for Recurrence- the PATHWay Study

An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants With Chronic Thyroid Eye Disease (TED)

A Phase 1 Study of of Anti-CD7 Allogeneic CAR-T Cell Therapy (WU-CART-007) in Patients With Relapsed or Refractory T-ALL/LBL

Pediatric Dose Optimization for Seizures in Emergency Medical Services

Galinpepimut-S Versus Investigator's Choice of Best Available Therapy for Maintenance in AML CR2/CRp2

An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants With Active Thyroid Eye Disease (TED)

Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Therapy-resistant CVU (Phase III)

A Study to Investigate the Safety and Efficacy of KER-012 in Combination With Background Therapy in Adult Participants With Pulmonary Arterial Hypertension (PAH) (TROPOS Study).

Proof-of-concept Study for SAR441344 (Frexalimab) in Relapsing Multiple Sclerosis