Clinical Trials in Ohio

Showing 11281-11300 of 20,938 trials

The Impact of Zinc Supplementation on Innate Immunity and Patient Safety in Sepsis

NCT02130388

Sepsis is the body's response to a life-threatening infection. This study will determine if zinc supplementation is safe to use in patients with severe sepsis or septic shock. This study will also gather preliminary information to evaluate the impact that zinc has on the immune system (the body's defense system against infection) and whether zinc can help monocytes and macrophages (specific types of cells that remove infections from the body) work more effectively.

Sepsis

Ohio State University10 participantsStarted May 2014

Columbus, Ohio, United States

COMPLETEDPhase 132 miles

Phase 1 Study of BXQ-350 in Adult Patients With Advanced Solid Tumors

NCT02859857

The objective of this study is to characterize the safety profile and determine the maximum tolerate dose (MTD) of BXQ-350, when given as a single agent at escalating doses, according to the investigational product (IP) related dose-limiting toxicities (DLTs) in patients with advanced solid tumors. Secondarily to assess the preliminary antitumor activity of BXQ-350 in solid tumors and recurrent high grade gliomas.

Neoplasms

Bexion Pharmaceuticals, Inc.86 participantsStarted Sep 2016

Lexington, Kentucky, United States • Albuquerque, New Mexico, United States • Cincinnati, Ohio, United States +1 more locations

TERMINATEDPhase 132 miles

A Study of BXQ-350 in Children and Young Adults With Relapsed Solid Tumors

NCT03967093

This study will evaluate the safety of BXQ-350 and determine the maximum tolerated dose (MTD) in children and young adults with relapsed solid tumors, including recurrent malignant brain tumors. All patients will receive BXQ-350 by intravenous (IV) infusion. The study is divided into two parts: Part 1 will enroll patients at increasing dose levels of BXQ-350 in order to determine the MTD. Part 2 will use the MTD to further assess the safety of BXQ-350 as well as preliminary anti-tumor activity.

Neoplasms

Bexion Pharmaceuticals, Inc.9 participantsStarted Apr 2019

Cincinnati, Ohio, United States • Columbus, Ohio, United States

The Impact of Zinc Supplementation on Innate Immunity and Patient Safety in Sepsis

Phase 1 Study of BXQ-350 in Adult Patients With Advanced Solid Tumors

A Study of BXQ-350 in Children and Young Adults With Relapsed Solid Tumors

Find Trials by Condition in Ohio

Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion

A Phase 3, Long-term Safety and Tolerability Study of ALKS 3831 in Adults With Schizophrenia

A Study to Understand the Genetics and Clinical Course of Focal Segmental Glomerulosclerosis (FSGS), Treatment-Resistant Minimal Change Disease (TR-MCD), and Diabetic Nephropathy (DN)

Follow-up Study of Growth, Safety, and Efficacy of an Infant Formula for Healthy Term Infants

Scoring System for Inhalation Injury

Efficacy and Safety of 26-Week Treatment of AR1001 in Patients With Mild to Moderate Alzheimer's Disease

A Long-term Safety Study of Olumacostat Glasaretil Gel in Subjects With Acne Vulgaris

A Study of Olumacostat Glasaretil Gel in Subjects With Acne Vulgaris

An Extension Study to Determine the Efficacy and Safety of STI571 in Participants With Chronic Myeloid Leukemia Who Are Refractory to or Intolerant of Interferon-Alpha

A Phase 3 Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Active Behçet's Disease

Phase 2/3 Study of IGSC, 20% in PIDD

Open Label Study of IV Brincidofovir in Adult Transplant Recipients With Adenovirus Viremia

Safety and Efficacy Study of Trans Sodium Crocetinate (TSC) in Newly Diagnosed Glioblastoma (GBM) Biopsy-Only Subjects

An Extension Study to Determine the Safety and Anti-Leukemic Effects of Imatinib Mesylate in Adult Participants With Ph+ Leukemia

Natural History Study of MNGIE

Study of IL-22 IgG2-Fc (F-652) for Subjects With Grade II-IV Lower GI aGVHD

Breast Mesh Used in Two-staged Breast Reconstruction